Evidence map›Paper›PMID 38860282›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2024

Neuroprotection provided by hypothermia initiated with high transnasal flow with ambient air in a model of pediatric cardiac arrest.

Zeng-Jin Yang, C Danielle Hopkins, Polan T Santos, Shawn Adams, Ewa Kulikowicz, Jennifer K Lee, Harikrishna Tandri, Raymond C Koehler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zeng-Jin YangDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
C Danielle HopkinsDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Polan T SantosDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Shawn AdamsDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Ewa KulikowiczDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Jennifer K LeeDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Harikrishna TandriDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Raymond C KoehlerDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.ORCID 0000-0002-5890-9992

Funding

Therapeutic Strategies for Neonatal Hypoxic-Ischemiic EncephalopathyR01NS060703 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES · 2008 to 2019
$3.9M
Use of transnasal air flow to cool and protect the brain after pediatric cardiac arrestR21NS095036 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES, TANDRI, HARIKRISHNA · 2016 to 2017
$446k
NINDS NIH HHS R01 NS060703NINDS NIH HHS R21 NS095036
6 · The paper itself

Abstract

Clinical trials of hypothermia after pediatric cardiac arrest (CA) have not seen robust improvement in functional outcome, possibly because of the long delay in achieving target temperature. Previous work in infant piglets showed that high nasal airflow, which induces evaporative cooling in the nasal mucosa, reduced regional brain temperature uniformly in half the time needed to reduce body temperature. Here, we evaluated whether initiation of hypothermia with high transnasal airflow provides neuroprotection without adverse effects in the setting of asphyxic CA. Anesthetized piglets underwent sham-operated procedures (

Indexed as

Disease Models, AnimalHeart ArrestHypothermia, InducedAnimalsAnimals, NewbornFemaleMaleNeuroprotectionSwineasphyxiacardiopulmonary resuscitationcerebral ischemiapigtherapeutic hypothermia

Identifiers

PMID38860282
PMCPMC11444505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.