ArticleFrontiers in endocrinology2024
Relationship between the longitudinal trajectory of the triglyceride-glucose index and the development of CKD: an 8-year retrospective longitudinal cohort study.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between triglyceride-glucose index and risk of chronic kidney disease: a meta-analysis.Renal failure · 2025Pooled it
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- Association of albumin trajectories and cumulative exposure with in-hospital mortality in acute pancreatitis: a retrospective cohort study.International journal of surgery (London, England) · 2026Article
- The triglyceride-glucose index in chronic kidney disease: a narrative review.Frontiers in nutrition · 2026Review
- Reciprocal mediation of immuno-inflammation and insulin resistance in the risk of chronic kidney disease among patients with coronary artery disease: insights from neutrophil-to-lymphocyte ratio and triglyceride-glucose index.Frontiers in immunology · 2026Article
- Triglyceride glucose index and atherogenic index of plasma predict rapid kidney function decline in cardiovascular-kidney-metabolic syndrome: the first longitudinal evidence from CHARLS.European journal of medical research · 2025Article
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- Elevated Serum Magnesium Levels May Delay the Loss of Residual Renal Function among Patients Receiving Peritoneal Dialysis: A Prospective Study.Biological trace element research · 2025Article
- The first-trimester triglyceride glucose-body mass index is a valuable predictor for adverse pregnancy outcomes.BMC pregnancy and childbirth · 2025Article
- Association of estimated glucose disposal rate with chronic kidney disease: comparative analysis against traditional insulin resistance indices.Frontiers in endocrinology · 2025Article
- The prognostic association of triglyceride-glucose index and its derived indicators with stable coronary artery disease patients undergoing percutaneous coronary intervention.Frontiers in endocrinology · 2025Article
- Association between cumulative average triglyceride glucose-body mass index and the risk of CKD onset.Frontiers in endocrinology · 2025Article
- Association between serum anion gap trajectory and mortality in hospitalized patients with sepsis: an analysis of the MIMIC-IV database.Frontiers in endocrinology · 2025Article
- Association of Dietary Diversity Trajectories With Depressive Symptoms in Chinese Older Adults: Findings From a Nationwide Population-Based Study.Depression and anxiety · 2025Article
- Identification and optimization of relevant factors for chronic kidney disease in abdominal obesity patients by machine learning methods: insights from NHANES 2005-2018.Lipids in health and disease · 2024Article
- The association of triglyceride-glucose index and combined obesity indicators with chest pain and risk of cardiovascular disease in American population with pre-diabetes or diabetes.Frontiers in endocrinology · 2024Article
- Article
Corrections and comments
- Erratum issued
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: The triglyceride-glucose (TyG) index, a simple surrogate marker of insulin resistance, is significantly associated with chronic kidney disease (CKD). However, there is limited research on the longitudinal trajectory of TyG index over time and its relationship with CKD. Objective: To analyse the characteristics of the longitudinal trajectory of the TyG index over time and its association with the development of CKD in a health check-up population. Methods: Participants who underwent at least three annual health check-ups at the Health Management Center of Sichuan Provincial People's Hospital from 2015 to 2022 were included in this retrospective cohort study. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. The latent class mixed model (LCMM) was used to identify the TyG index trajectory of the study population. A Cox proportional hazard model was used to estimate the CKD incidence risk in different quartile groups and the association of changes in the TyG index trajectory with the development of CKD. Results: A total of 4,921 participants were included in this study, and they were divided into four groups according to the quartiles of the baseline TyG index: Q1 (5.43-6.66), Q2 (6.67-7.04), Q3 (7.05-7.43), and Q4 (7.43-9.97). There was no difference in the risk of CKD occurrence among the TyG groups. Three different TyG index trajectories were identified in this study: a high-level group, middle-level stable group and low-level stable group, respectively. The incidence rate of CKD in the high-level TyG index trajectory group was 2.399 times greater than that in the low-level stable trajectory group (HR=2.399, 95% CI 1.167-4.935). Conclusion: Individuals with long-term exposure to high TyG index levels had a significantly greater risk of CKD. Routine monitoring of the TyG index and its longitudinal trend will aid in the risk stratification of CKD in the general population and will be helpful for CKD prevention and targeted management.
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