Evidence map›Paper›PMID 38858780›Full record

ArticleJournal of nanobiotechnology2024

Bacterial outer membrane vesicle-cancer cell hybrid membrane-coated nanoparticles for sonodynamic therapy in the treatment of breast cancer bone metastasis.

Jiahao Wang, Shuailong Liang, Sijie Chen, Tianliang Ma, Mingyu Chen, Chengcheng Niu, Yi Leng, Long Wang

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Multifunctional CuFrontiers in chemistry · 2026
    Review
  11. Article
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  15. Article
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  17. Sonodynamic biomimetic-nanomedicine fight cancers.Journal of nanobiotechnology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jiahao Wang *The School of Medicine, Nankai University, Tianjin, 300071, China.
Shuailong Liang *Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Sijie ChenDepartment of Ultrasound Diagnosis, Second Xiangya Hospital, Central South University, Changsha, China.
Tianliang MaDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Mingyu ChenDepartment of Ultrasound Diagnosis, Second Xiangya Hospital, Central South University, Changsha, China.
Chengcheng NiuDepartment of Ultrasound Diagnosis, Second Xiangya Hospital, Central South University, Changsha, China.
Yi LengDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Long WangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China. dr_wanglong@csu.edu.cn.

Funding

Health Commission of Hunan Province C202304077431Key Research and Development Program of Hunan Province of China 2021SK2005Natural Science Foundation of Hunan Province 2022JJ30962
6 · The paper itself

Abstract

Breast cancer bone metastasis is a terminal-stage disease and is typically treated with radiotherapy and chemotherapy, which causes severe side effects and limited effectiveness. To improve this, Sonodynamic therapy may be a more safe and effective approach in the future. Bacterial outer membrane vesicles (OMV) have excellent immune-regulating properties, including modulating macrophage polarization, promoting DC cell maturation, and enhancing anti-tumor effects. Combining OMV with Sonodynamic therapy can result in synergetic anti-tumor effects. Therefore, we constructed multifunctional nanoparticles for treating breast cancer bone metastasis. We fused breast cancer cell membranes and bacterial outer membrane vesicles to form a hybrid membrane (HM) and then encapsulated IR780-loaded PLGA with HM to produce the nanoparticles, IR780@PLGA@HM, which had tumor targeting, immune regulating, and Sonodynamic abilities. Experiments showed that the IR780@PLGA@HM nanoparticles had good biocompatibility, effectively targeted to 4T1 tumors, promoted macrophage type I polarization and DC cells activation, strengthened anti-tumor inflammatory factors expression, and presented the ability to effectively kill tumors both in vitro and in vivo, which showed a promising therapeutic effect on breast cancer bone metastasis. Therefore, the nanoparticles we constructed provided a new strategy for effectively treating breast cancer bone metastasis.

Indexed as

Bacterial Outer MembraneBone NeoplasmsBreast NeoplasmsMice, Inbred BALB CAnimalsCell Line, TumorCell MembraneFemaleHumansMiceMultifunctional NanoparticlesNanoparticlesPolylactic Acid-Polyglycolic Acid CopolymerRAW 264.7 CellsUltrasonic TherapyPolylactic Acid-Polyglycolic Acid CopolymerBacterial outer membrane vesicleBiomimetic nanoparticlesBreast cancer bone metastasisHybrid membraneSonodynamic therapy

Identifiers

PMID38858780
PMCPMC11165797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.