Evidence map›Paper›PMID 38858611›Full record

ArticleBMC pregnancy and childbirth2024

Maternal serum biomarkers of placental insufficiency at 24-28 weeks of pregnancy in relation to the risk of delivering small-for-gestational-age infant in Sylhet, Bangladesh: a prospective cohort study.

Sayedur Rahman, Md Shafiqul Islam, Anjan Kumar Roy, Tarik Hasan, Nabidul Haque Chowdhury, Salahuddin Ahmed, Rubhana Raqib, Abdullah H Baqui, Rasheda Khanam

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Article in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Sayedur RahmanDepartment of Women's and Children's Health, Uppsala University, Akademiska sjukhuset, Uppsala, SE- 751 85, Sweden. sayedbir@gmail.com.
Md Shafiqul IslamProjahnmo Research Foundation, Banani, Dhaka, 1213, Bangladesh.
Anjan Kumar RoyInternational Center for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh.
Tarik HasanProjahnmo Research Foundation, Banani, Dhaka, 1213, Bangladesh.
Nabidul Haque ChowdhuryProjahnmo Research Foundation, Banani, Dhaka, 1213, Bangladesh.
Salahuddin AhmedProjahnmo Research Foundation, Banani, Dhaka, 1213, Bangladesh.
Rubhana RaqibInternational Center for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh.
Abdullah H BaquiDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD, 21205, USA. abaqui@jhu.edu.
Rasheda KhanamDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD, 21205, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmall-for-gestational-age (SGA), commonly caused by poor placentation, is a major contributor to global perinatal mortality and morbidity. Maternal serum levels of placental protein and angiogenic factors are changed in SGA. Using data from a population-based pregnancy cohort, we estimated the relationships between levels of second-trimester pregnancy-associated plasma protein-A (PAPP-A), placental growth factor (PlGF), and serum soluble fms-like tyrosine kinase-1 (sFlt-1) with SGA.

methodsThree thousand pregnant women were enrolled. Trained health workers prospectively collected data at home visits. Maternal blood samples were collected, serum aliquots were prepared and stored at -80℃. Included in the analysis were 1,718 women who delivered a singleton live birth baby and provided a blood sample at 24-28 weeks of gestation. We used Mann-Whitney U test to examine differences of the median biomarker concentrations between SGA (< 10th centile birthweight for gestational age) and appropriate-for-gestational-age (AGA). We created biomarker concentration quartiles and estimated the risk ratios (RRs) and 95% confidence intervals (CIs) for SGA by quartiles separately for each biomarker. A modified Poisson regression was used to determine the association of the placental biomarkers with SGA, adjusting for potential confounders.

resultsThe median PlGF level was lower in SGA pregnancies (934 pg/mL, IQR 613-1411 pg/mL) than in the AGA (1050 pg/mL, IQR 679-1642 pg/mL; p < 0.001). The median sFlt-1/PlGF ratio was higher in SGA pregnancies (2.00, IQR 1.18-3.24) compared to AGA pregnancies (1.77, IQR 1.06-2.90; p = 0.006). In multivariate regression analysis, women in the lowest quartile of PAPP-A showed 25% higher risk of SGA (95% CI 1.09-1.44; p = 0.002). For PlGF, SGA risk was higher in women in the lowest (aRR 1.40, 95% CI 1.21-1.62; p < 0.001) and 2nd quartiles (aRR 1.30, 95% CI 1.12-1.51; p = 0.001). Women in the highest and 3rd quartiles of sFlt-1 were at reduced risk of SGA delivery (aRR 0.80, 95% CI 0.70-0.92; p = 0.002, and aRR 0.86, 95% CI 0.75-0.98; p = 0.028, respectively). Women in the highest quartile of sFlt-1/PlGF ratio showed 18% higher risk of SGA delivery (95% CI 1.02-1.36; p = 0.025).

conclusionsThis study provides evidence that PAPP-A, PlGF, and sFlt-1/PlGF ratio measurements may be useful second-trimester biomarkers for SGA.

Indexed as

BiomarkersInfant, Small for Gestational AgePlacenta Growth FactorPlacental InsufficiencyPregnancy-Associated Plasma Protein-APregnancy Trimester, SecondVascular Endothelial Growth Factor Receptor-1AdultBangladeshFemaleGestational AgeHumansInfant, NewbornPregnancyProspective StudiesRisk FactorsBiomarkersFLT1 protein, humanPGF protein, humanPlacenta Growth FactorPregnancy-Associated Plasma Protein-AVascular Endothelial Growth Factor Receptor-1BangladeshBiomarkersCohort studyPlacental growth factorPlacental insufficiencyPregnancy-associated plasma protein-ASerum soluble fms-like tyrosine kinase-1Small-for-gestational-age

Identifiers

PMID38858611
PMCPMC11163798

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.