ArticleNature neuroscience2024
A shifting role of thalamocortical connectivity in the emergence of cortical functional organization.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Disrupted thalamic functional hierarchy on resting-state fMRI in idiopathic generalized epilepsy.European radiology experimental · 2026Article
- Mapping the dual functional organization of the substantia nigra.Molecular psychiatry · 2026Article
- Early-life medial pulvinar disruption drives schizophrenia-relevant prefrontal inhibitory and cognitive deficits in primates.bioRxiv : the preprint server for biology · 2026Article
- Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.bioRxiv : the preprint server for biology · 2026Article
- Structural MRI across lifespan reveals differential thalamic trajectories in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Article
- Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices.Nature communications · 2026Article
- Developmental variations in recurrent spatiotemporal brain propagations from childhood to adulthood.Nature communications · 2026Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children.Nature communications · 2025Article
- Geometric constraints on the architecture of mammalian cortical connectomes.bioRxiv : the preprint server for biology · 2025Article
- Connectome-constrained ligand-receptor interaction analysis for understanding brain network communication.Nature communications · 2025Article
- A hierarchical model of early brain functional network development.Trends in cognitive sciences · 2025Review
- Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity.Nature neuroscience · 2025Article
- Structure-function coupling in the first month of life: Associations with age and attention.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Anterior-posterior systematic deficits of cortical thickness in early-onset schizophrenia.Communications biology · 2025Article
- Topographic Axes of Wiring Space Converge to Genetic Topography in Shaping the Human Cortical Layout.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A multimodal characterization of low-dimensional thalamocortical structural connectivity patterns.Communications biology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
Abstract
The cortical patterning principle has been a long-standing question in neuroscience, yet how this translates to macroscale functional specialization in the human brain remains largely unknown. Here we examine age-dependent differences in resting-state thalamocortical connectivity to investigate its role in the emergence of large-scale functional networks during early life, using a primarily cross-sectional but also longitudinal approach. We show that thalamocortical connectivity during infancy reflects an early differentiation of sensorimotor networks and genetically influenced axonal projection. This pattern changes in childhood, when connectivity is established with the salience network, while decoupling externally and internally oriented functional systems. A developmental simulation using generative network models corroborated these findings, demonstrating that thalamic connectivity contributes to developing key features of the mature brain, such as functional segregation and the sensory-association axis, especially across 12-18 years of age. Our study suggests that the thalamus plays an important role in functional specialization during development, with potential implications for studying conditions with compromised internal and external processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.