Evidence map›Paper›PMID 38858579›Full record

ArticleNature reviews. Neuroscience2024

Fear, anxiety and the functional architecture of the human central extended amygdala.

Alexander J Shackman, Shannon E Grogans, Andrew S Fox

Abstract readLetter
In one paragraph

Article in Nature reviews. Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Anxiety disorders: a cross-sectional study of clinical and biological associations.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Fear, anxiety, and the extended amygdala-bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. A Shared Threat-Anticipation Circuit Is Dynamically Engaged at Different Moments by Certain and Uncertain Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexander J ShackmanDepartment of Psychology, University of Maryland, College Park, College Park, MD, USA. shackman@umd.edu.
Shannon E GrogansDepartment of Psychology, University of Maryland, College Park, College Park, MD, USA.
Andrew S FoxDepartment of Psychology, University of California, Davis, Davis, CA, USA.

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
LIFE-SPAN DEVELOPMENT OF NORMAL AND ABNORMAL BEHAVIORT32MH018921 · NIMH · VANDERBILT UNIVERSITY · PI HUMPHREYS, KATHRYN LEIGH · 1989 to 2024
$6.7M
Engineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across SpeciesUF1MH128336 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI FOX, ANDREW S, GRADINARU, VIVIANA · 2021 to 2021
$6.1M
Using Theory- and Data-Driven Neurocomputational Approaches and Digital Phenotyping to Understand RDoC Acute and Potential ThreatR01MH131264 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI ALEXANDER JOSEPH SHACKMAN · 2022 to 2026
$3.9M
Using Multimodal Neuroimaging and Real-World Experience Sampling to Understand Negative Affect and Paranoid Ideation in PsychosisR01MH121409 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI BLANCHARD, JACK J., SHACKMAN, ALEXANDER JOSEPH · 2020 to 2024
$3.7M
ORIGINS AND EMERGENCE OF MALADAPTIVE SOCIOEMOTIONAL BEHAVIOR DURING THE TRANSITION TO ADULTHOOD IN PRIMATESR01MH121735 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FOX, ANDREW S · 2020 to 2025
$3.6M
Prospective Determination of Neurobehavioral Risk for the Development of Emotion DisordersR01MH107444 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI SHACKMAN, ALEXANDER JOSEPH · 2016 to 2020
$3.4M
Using Computational Neuroimaging and Extended Smartphone Assessment to Understand the Pathways Linking Threat-Related Brain Circuits to Alcohol Misuse Across AdulthoodR01AA030042 · NIAAA · UNIV OF MARYLAND, COLLEGE PARK · PI ALEXANDER JOSEPH SHACKMAN · 2023 to 2026
$2.5M
The Role of Anxiety-Related Brain Circuits in Tobacco Dependence and WithdrawalR21DA040717 · NIDA · UNIV OF MARYLAND, COLLEGE PARK · PI SHACKMAN, ALEXANDER JOSEPH · 2016 to 2017
$418k
Rethinking the Neural Correlates of Uncertain Threat Anticipation with a Statistical Learning ApproachR21MH129851 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FOX, ANDREW S · 2022 to 2023
$414k
Using Functional Neuroimaging and Smartphone Digital Phenotyping to Understand the Emergence of Internalizing IllnessF31MH132280 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI GROGANS, SHANNON · 2023 to 2024
$97k
NIAAA NIH HHS R01 AA030042NIDA NIH HHS R21 DA040717NIH HHS P51 OD011107NIMH NIH HHS F31 MH132280NIMH NIH HHS R01 MH107444NIMH NIH HHS R01 MH121409NIMH NIH HHS R01 MH121735NIMH NIH HHS R01 MH131264NIMH NIH HHS R21 MH129851NIMH NIH HHS T32 MH018921NIMH NIH HHS UF1 MH128336
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnxietyFearAmygdalaCentral Amygdaloid NucleusHumans

Identifiers

PMID38858579
PMCPMC11262955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.