ArticleScientific reports2024
A cross-sectional National Health and Nutrition Examination survey-based study of the association between systemic immune-inflammation index and blood urea nitrogen levels in United States adolescents.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Association between blood urea nitrogen-to-albumin ratio and mortality among atrial fibrillation patients admitted to the intensive care unit.BMC cardiovascular disorders · 2026Article
- Blood Urea Nitrogen to Albumin Ratio is Associated with Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Association between blood urea nitrogen and the prevalence of Hashimoto's thyroiditis in adults with type 2 diabetes mellitus: a cross-sectional study.Frontiers in nutrition · 2026Article
- Genetic insights into blood urea nitrogen as a risk factor for coronary artery disease: a Mendelian randomization study in East Asians.Renal failure · 2025Article
- A nomogram based on trauma-induced coagulopathy for predicting hospital mortality in multi-trauma patients: a retrospective study.Internal and emergency medicine · 2025Article
- Association between platelet-to-lymphocyte ratio and blood urea nitrogen levels in pediatric populations: evidence from the NHANES (2009-2018).Translational pediatrics · 2025Article
- Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes.World journal of diabetes · 2025Article
- The association between blood urea nitrogen to albumin ratio and cognitive function in Parkinson's disease patients.Frontiers in neurology · 2025Article
- Association of blood urea nitrogen to serum albumin ratio with arterial stiffness in type 2 diabetes patients: a Chinese cross-sectional study.Frontiers in endocrinology · 2025Article
- The association between blood urea nitrogen to serum albumin ratio and 28 day in-hospital mortality in patients with chronic heart failure and sepsis: a pilot retrospective study.Frontiers in cardiovascular medicine · 2025Article
- Article
- Hematological and Serum Biochemical Profiles of the Southern Red Muntjac (Veterinary medicine international · 2025Article
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5 authors.
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Abstract
Blood urea nitrogen (BUN) level is one of the commonly used indicators to assess renal function and systemic immune-inflammatory status. In the adolescent population, changes in BUN levels may be associated with a variety of factors, including physiologic dehydration, lifestyle influences such as nutritional intake, physical activity, and possible endocrine or metabolic disorders. In recent years, more and more studies have shown that BUN levels are not only a reflection of kidney function, but it may also be related to the inflammatory state of the body. The Systemic Immune Inflammatory Index (SII) is a comprehensive index that takes into account platelet counts, neutrophil and lymphocyte counts, and is thought to be effective in reflecting the body's immune status and inflammatory response. However, research on the relationship between the two, SII and BUN, remains understudied in the adolescent population. The purpose of this study was to examine the relationship between SII and BUN levels in a population of American adolescents and to further analyze the factors that influence it. We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) database. Using descriptive statistics, correlation analysis, and regression analysis, we explored the relationship between SII and BUN levels. We found a significant negative correlation between SII and BUN levels, with BUN levels decreasing when SII levels increased (BUN as the dependent variable and SII as the outcome variable). We performed a multiple regression analysis of this relationship, controlling for possible confounders such as gender, age, race, and BMI, and found that this negative correlation remained significant. Our findings reveal an important relationship between SII and BUN levels and provide new perspectives for understanding adolescent health.
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