ArticleScientific reports2024
In situ brain tumor detection using a Raman spectroscopy system-results of a multicenter study.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Illuminating glioma surgery: A meta-analysis of Raman spectroscopy for intraoperative decision-making.Neurosurgical review · 2025Pooled it
- Rapid serum-based differentiation of ovarian tumors and assessment of post-treatment disease-free status using portable Raman spectroscopy and machine learning.Analytical and bioanalytical chemistry · 2026Article
- Shining a light on brain tumors: a review of Raman spectroscopy in the operating room.Journal of biomedical optics · 2026Review
- Label-free wide-field imaging of brain tumors using near-infrared endogenous fluorescence and reflectance normalization.Journal of biomedical optics · 2026Article
- Integration of Raman spectroscopy and chemometric modeling to study lactose effects on human glioblastoma brain cells.RSC advances · 2026Article
- Combining label-free Raman spectroscopy with machine learning to monitor COVID-19 disease from acute infection to recovery.Journal of biomedical optics · 2026Article
- Combined multi-omics and multi-spectral profiling of plasma extracellular vesicles reveals liquid biopsy biomarkers for glioma diagnosis.Cell reports. Medicine · 2026Article
- Raman spectroscopy as a diagnostic tool for glioma: protocol for a systematic review.Diagnostic and prognostic research · 2026Review
- Article
- Machine-Learning-Enabled Raman Spectroscopy Refines Indocyanine Green Fluorescence Boundaries for Precise Glioblastoma Margin Delineation.Research (Washington, D.C.) · 2026Article
- Spectral discrimination of pediatric SF188 and adult glioblastoma stem cells by deep learning-enhanced Raman profiling.Frontiers in oncology · 2026Article
- Image-Guided Brain Tumor Surgery.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Relevance of light conditions for clinicalFrontiers in oncology · 2026Article
- Label-free molecular profiling of cancer using Raman spectroscopy: from fundamentals to clinical applications.Frontiers in oncology · 2026Review
- Review
- Experimental method to assess depth sensing limits of inelastic scattering measurements using spatial-offset Raman spectroscopy imaging.Journal of biomedical optics · 2025Article
- Challenges and opportunities for new intraoperative optical techniques in the surgical treatment of pituitary adenomas: a review.Journal of biomedical optics · 2025Review
- Deployment of a real-time prostate cancer confirmation system with Raman spectroscopy: fine-tuning versus test-time adaptation of 1D CNNs.Biophotonics discovery · 2025Article
- Development of a rapid and novel diagnostic technique for cardiac amyloidosis using Raman spectroscopy.Research square · 2025Article
- Intraoperative use of high-speed Raman spectroscopy during soft tissue sarcoma resection.Scientific reports · 2025Article
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Authors and funding
22 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Safe and effective brain tumor surgery aims to remove tumor tissue, not non-tumoral brain. This is a challenge since tumor cells are often not visually distinguishable from peritumoral brain during surgery. To address this, we conducted a multicenter study testing whether the Sentry System could distinguish the three most common types of brain tumors from brain tissue in a label-free manner. The Sentry System is a new real time, in situ brain tumor detection device that merges Raman spectroscopy with machine learning tissue classifiers. Nine hundred and seventy-six in situ spectroscopy measurements and colocalized tissue specimens were acquired from 67 patients undergoing surgery for glioblastoma, brain metastases, or meningioma to assess tumor classification. The device achieved diagnostic accuracies of 91% for glioblastoma, 97% for brain metastases, and 96% for meningiomas. These data show that the Sentry System discriminated tumor containing tissue from non-tumoral brain in real time and prior to resection.
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