Evidence map›Paper›PMID 38858372›Full record

ArticleNature communications2024

Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers.

Jiahao Zhuang, Guobin Qi, Yecheng Feng, Min Wu, Hang Zhang, Dandan Wang, Xianhe Zhang, Kok Chan Chong, Bowen Li, Shitai Liu and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Chemical science · 2026
    Article
  5. Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. pH-Responsive AIE Photosensitizers for Enhanced Antibacterial Therapy.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiahao Zhuang *Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, China.
Guobin Qi *Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.
Yecheng FengInstitute of Precision Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, China.
Min WuJoint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, China.
Hang ZhangDepartment of Materials Science and Engineering, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-5570-8522
Dandan WangJoint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, China.
Xianhe ZhangDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-6786-9048
Kok Chan ChongDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.
Bowen LiDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.
Shitai LiuJoint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, China.
Jianwu TianDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.
Yi ShanDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore.
Duo MaoInstitute of Precision Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, China. maod6@mail.sysu.edu.cn.
Bin LiuJoint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, China. cheliub@nus.edu.sg.ORCID http://orcid.org/0000-0002-0956-2777

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32271375National Research Foundation Singapore (National Research Foundation-Prime Minister's office, Republic of Singapore) A-0009163-01-00National University of Singapore (NUS) E-467-00-0012-02
6 · The paper itself

Abstract

The development of Type I photosensitizers (PSs) is of great importance due to the inherent hypoxic intolerance of photodynamic therapy (PDT) in the hypoxic microenvironment. Compared to Type II PSs, Type I PSs are less reported due to the absence of a general molecular design strategy. Herein, we report that the combination of typical Type II PS and natural substrate carvacrol (CA) can significantly facilitate the Type I pathway to efficiently generate superoxide radical (O

Indexed as

BenzoquinonesPhotochemotherapyPhotosensitizing AgentsStaphylococcus aureusAnimalsAnti-Bacterial AgentsCymenesElectron TransportFemaleHumansLightMiceMice, Inbred BALB CSinglet OxygenStaphylococcal InfectionsSuperoxidesAnti-Bacterial AgentsBenzoquinonescarvacrolCymenesPhotosensitizing AgentsSinglet OxygenSuperoxidesthymoquinone

Identifiers

PMID38858372
PMCPMC11164902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.