ArticleNature communications2024
Heterogeneous associations of multiplexed environmental factors and multidimensional aging metrics.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Green Environments for Sustainable Brains: Parameters Shaping Adaptive Neuroplasticity and Lifespan Neurosustainability-A Systematic Review and Future Directions.International journal of environmental research and public health · 2025Pooled it
- Associations of Green Space and Air Pollution Mixture with Heterogeneous Biological Aging Patterns.Environmental health perspectives · 2026Article
- A large cohort analysis of metabolic signatures underlying the liver-eye axis.Communications medicine · 2026Article
- The exposome of brain aging across 34 countries.Nature medicine · 2026Article
- Modifying Role of Sustainable Diets on the Association Between Particulate Matter and Biological Aging: The Guangzhou Biobank Cohort Study.Aging cell · 2026Article
- The mitigation effects of residential green space and low air pollution on socioeconomic inequalities in depression.Npj mental health research · 2025Article
- Long-Term High-Altitude Exposure, Accelerated Aging, and Multidimensional Aging-Related Changes.JAMA network open · 2025Article
- Urban physical activity for neurogenesis: infrastructure limitations.Frontiers in public health · 2025Article
- Environmental and Climate Impacts on Physiological Aging: Comprehensive Pathways to Enhanced Age-related Resilience.Aging and disease · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Complicated associations between multiplexed environmental factors and aging are poorly understood. We manipulated aging using multidimensional metrics such as phenotypic age, brain age, and brain volumes in the UK Biobank. Weighted quantile sum regression was used to examine the relative individual contributions of multiplexed environmental factors to aging, and self-organizing maps (SOMs) were used to examine joint effects. Air pollution presented a relatively large contribution in most cases. We also found fair heterogeneities in which the same environmental factor contributed inconsistently to different aging metrics. Particulate matter contributed the most to variance in aging, while noise and green space showed considerable contribution to brain volumes. SOM identified five subpopulations with distinct environmental exposure patterns and the air pollution subpopulation had the worst aging status. This study reveals the heterogeneous associations of multiplexed environmental factors with multidimensional aging metrics and serves as a proof of concept when analyzing multifactors and multiple outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.