Evidence map›Paper›PMID 38858301›Full record

ArticleMolecular biotechnology2025

MicroRNA-361-5p Alleviates Leydig Cell Apoptosis and Promotes Cell Growth by Targeting PIAS1 in Late-Onset Hypogonadism.

Xunrong Zhou, Chunsheng Ben, Dong Wu, Anle Xia, Ping'an Chang, Bin He, Ninghan Feng, Cheng Wu

Abstract read
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Article in Molecular biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xunrong ZhouMedical College of Nantong University, 9 Qiangyuan Road, Nantong, 226001, China.
Chunsheng BenDepartment of Urology, The Affiliated Dongtai Hospital of Nantong University, Kangfu West Rord, Dongtai, Yancheng, 224200, China.
Dong WuDepartment of Urology, The Affiliated Dongtai Hospital of Nantong University, Kangfu West Rord, Dongtai, Yancheng, 224200, China.
Anle XiaDepartment of Urology, The Affiliated Dongtai Hospital of Nantong University, Kangfu West Rord, Dongtai, Yancheng, 224200, China.
Ping'an ChangDepartment of Urology, The Affiliated Dongtai Hospital of Nantong University, Kangfu West Rord, Dongtai, Yancheng, 224200, China.
Bin HeDepartment of Urology, The Affiliated Dongtai Hospital of Nantong University, Kangfu West Rord, Dongtai, Yancheng, 224200, China.
Ninghan FengMedical College of Nantong University, 9 Qiangyuan Road, Nantong, 226001, China. n.feng@njmu.edu.cn.
Cheng WuDepartment of Urology, The Affiliated Dongtai Hospital of Nantong University, Kangfu West Rord, Dongtai, Yancheng, 224200, China. wudaifu110@hotmail.com.ORCID http://orcid.org/0009-0005-8768-6109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late-onset hypogonadism (LOH) is an age-related syndrome characterized by deficiency of serum testosterone produced by Leydig cells. Previous evidence suggested that microRNA (miR)-361-3p can serve as a promising biomarker for LOH. Nonetheless, its detailed function and molecular mechanism in LOH remain unclarified. The 24-month-old male mice were selected as an animal LOH model, and mouse Leydig cell line TM3 was stimulated with H

Indexed as

ApoptosisHypogonadismLeydig CellsMicroRNAsProtein Inhibitors of Activated STATAnimalsCell LineCell ProliferationDisease Models, AnimalHydrogen PeroxideMaleMiceTestosteroneHydrogen PeroxideMicroRNAsProtein Inhibitors of Activated STATTestosteroneLate-onset hypogonadismLeydig cellsmicroRNA (miR)-361-3pTestosterone

Identifiers

PMID38858301

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.