Evidence map›Paper›PMID 38858290›Full record

ArticleActa neurologica Belgica2024

Rituximab maintenance treatment outcomes in patients with relapsing neuromyelitis optica spectrum disorder: a monocentric retrospective analysis.

Lianchen Xiao, Yanning Huang, Hui Sun, Sai Gao, Dehui Huang, Lei Wu

Abstract read
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In one paragraph

Article in Acta neurologica Belgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lianchen XiaoDepartment of Neurology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
Yanning HuangSchool of Medicine, Nankai University, Tianjin, China.
Hui SunDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.
Sai GaoDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.
Dehui HuangDepartment of Neurology, Chinese PLA General Hospital, Beijing, China. huangdehui@gmail.com.
Lei WuDepartment of Neurology, Chinese PLA General Hospital, Beijing, China. wlyingsh@163.com.ORCID http://orcid.org/0000-0002-5146-2630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some patients with neuromyelitis optica spectrum disorder (NMOSD) experience relapse after rituximab (RTX) treatment. In this retrospective study, we analyzed the recurrence-related clinical features, laboratory investigation results, and dosing protocol of 30 female patients with relapsing NMOSD with immunoglobulin G autoantibodies against aquaporin-4 and relapses during repeated 0.5 g RTX infusions as maintenance treatment. The median follow-up period was 6.62 years. Thirty-five episodes were observed, with myelitis being the most frequent. The median expanded disability status scale change score was 0.50. The recurrence rate decreased by 44.23%/year with RTX infusion. Approximately 85.71% of the patients showed relapse without RTX infusion within 10 months. Overall, RTX may be effective for relapsing NMOSD cases.

Indexed as

Immunologic FactorsNeuromyelitis OpticaRecurrenceRituximabAdolescentAdultAquaporin 4AutoantibodiesFemaleFollow-Up StudiesHumansMiddle AgedRetrospective StudiesTreatment OutcomeYoung AdultAquaporin 4AutoantibodiesImmunologic FactorsRituximabMaintenance treatmentNeuromyelitis optica spectrum disorderRelapseRelapsing NMOSDRituximab

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.