ArticleNeurology2024
Associations of Epigenetic Age Estimators With Cognitive Function Trajectories in the Women's Health Initiative Memory Study.
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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
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What it found
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Who cites it
10 citing papers in PubMed.
- Changes in DNA methylation-based aging predicts brain damage and dementia and reflects life-course cardiovascular risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.Biological psychiatry global open science · 2026Review
- Article
- Accelerated epigenetic aging as a modifier of homocysteine-associated cognitive decline: Findings from NHANES.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study.Aging cell · 2026Article
- Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration.medRxiv : the preprint server for health sciences · 2026Article
- Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Estimating cognitive decline in longitudinal studies with high mortality and a long interwave period: A comparison of approaches and considerations around integrating end-of-life interview data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Epigenetic clocks of biological aging and risk of incident mild cognitive impairment and dementia: the Women's Health Initiative Memory Study.medRxiv : the preprint server for health sciences · 2025Article
- Article
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Authors and funding
9 authors.
Steve NguyenFrom the Division of Epidemiology (S.N., L.K.M., A.H.S.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla; Kaiser Permanente Washington Health Research Institute (L.K.M.), Seattle, WA; Departments of Internal Medicine and Biostatistics and Data Science (M.A.E.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (E.A.W.), Gillings School of Global Public Health; Department of Medicine (E.A.W.), School of Medicine, University of North Carolina, Chapel Hill; Altos Labs (A.L., S.H.), San Diego, CA; Department of Epidemiology (S.H.), UCLA Fielding School of Public Health, Los Angeles, CA; Division of Preventive Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry & Behavioral Medicine (S.R.R.), Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics, Gerontology, and Palliative Care (A.H.S.), Department of Medicine, University of California, San Diego, La Jolla.ORCID 0000-0002-5193-7042
Linda K McEvoyFrom the Division of Epidemiology (S.N., L.K.M., A.H.S.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla; Kaiser Permanente Washington Health Research Institute (L.K.M.), Seattle, WA; Departments of Internal Medicine and Biostatistics and Data Science (M.A.E.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (E.A.W.), Gillings School of Global Public Health; Department of Medicine (E.A.W.), School of Medicine, University of North Carolina, Chapel Hill; Altos Labs (A.L., S.H.), San Diego, CA; Department of Epidemiology (S.H.), UCLA Fielding School of Public Health, Los Angeles, CA; Division of Preventive Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry & Behavioral Medicine (S.R.R.), Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics, Gerontology, and Palliative Care (A.H.S.), Department of Medicine, University of California, San Diego, La Jolla.
Mark A EspelandFrom the Division of Epidemiology (S.N., L.K.M., A.H.S.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla; Kaiser Permanente Washington Health Research Institute (L.K.M.), Seattle, WA; Departments of Internal Medicine and Biostatistics and Data Science (M.A.E.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (E.A.W.), Gillings School of Global Public Health; Department of Medicine (E.A.W.), School of Medicine, University of North Carolina, Chapel Hill; Altos Labs (A.L., S.H.), San Diego, CA; Department of Epidemiology (S.H.), UCLA Fielding School of Public Health, Los Angeles, CA; Division of Preventive Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry & Behavioral Medicine (S.R.R.), Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics, Gerontology, and Palliative Care (A.H.S.), Department of Medicine, University of California, San Diego, La Jolla.
Eric A WhitselFrom the Division of Epidemiology (S.N., L.K.M., A.H.S.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla; Kaiser Permanente Washington Health Research Institute (L.K.M.), Seattle, WA; Departments of Internal Medicine and Biostatistics and Data Science (M.A.E.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (E.A.W.), Gillings School of Global Public Health; Department of Medicine (E.A.W.), School of Medicine, University of North Carolina, Chapel Hill; Altos Labs (A.L., S.H.), San Diego, CA; Department of Epidemiology (S.H.), UCLA Fielding School of Public Health, Los Angeles, CA; Division of Preventive Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry & Behavioral Medicine (S.R.R.), Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics, Gerontology, and Palliative Care (A.H.S.), Department of Medicine, University of California, San Diego, La Jolla.ORCID 0000-0003-4843-3641
Ake LuFrom the Division of Epidemiology (S.N., L.K.M., A.H.S.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla; Kaiser Permanente Washington Health Research Institute (L.K.M.), Seattle, WA; Departments of Internal Medicine and Biostatistics and Data Science (M.A.E.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (E.A.W.), Gillings School of Global Public Health; Department of Medicine (E.A.W.), School of Medicine, University of North Carolina, Chapel Hill; Altos Labs (A.L., S.H.), San Diego, CA; Department of Epidemiology (S.H.), UCLA Fielding School of Public Health, Los Angeles, CA; Division of Preventive Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry & Behavioral Medicine (S.R.R.), Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics, Gerontology, and Palliative Care (A.H.S.), Department of Medicine, University of California, San Diego, La Jolla.
Steve HorvathFrom the Division of Epidemiology (S.N., L.K.M., A.H.S.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla; Kaiser Permanente Washington Health Research Institute (L.K.M.), Seattle, WA; Departments of Internal Medicine and Biostatistics and Data Science (M.A.E.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (E.A.W.), Gillings School of Global Public Health; Department of Medicine (E.A.W.), School of Medicine, University of North Carolina, Chapel Hill; Altos Labs (A.L., S.H.), San Diego, CA; Department of Epidemiology (S.H.), UCLA Fielding School of Public Health, Los Angeles, CA; Division of Preventive Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry & Behavioral Medicine (S.R.R.), Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics, Gerontology, and Palliative Care (A.H.S.), Department of Medicine, University of California, San Diego, La Jolla.
Joann E MansonFrom the Division of Epidemiology (S.N., L.K.M., A.H.S.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla; Kaiser Permanente Washington Health Research Institute (L.K.M.), Seattle, WA; Departments of Internal Medicine and Biostatistics and Data Science (M.A.E.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (E.A.W.), Gillings School of Global Public Health; Department of Medicine (E.A.W.), School of Medicine, University of North Carolina, Chapel Hill; Altos Labs (A.L., S.H.), San Diego, CA; Department of Epidemiology (S.H.), UCLA Fielding School of Public Health, Los Angeles, CA; Division of Preventive Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry & Behavioral Medicine (S.R.R.), Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics, Gerontology, and Palliative Care (A.H.S.), Department of Medicine, University of California, San Diego, La Jolla.ORCID 0000-0002-9426-7595
Stephen R RappFrom the Division of Epidemiology (S.N., L.K.M., A.H.S.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla; Kaiser Permanente Washington Health Research Institute (L.K.M.), Seattle, WA; Departments of Internal Medicine and Biostatistics and Data Science (M.A.E.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (E.A.W.), Gillings School of Global Public Health; Department of Medicine (E.A.W.), School of Medicine, University of North Carolina, Chapel Hill; Altos Labs (A.L., S.H.), San Diego, CA; Department of Epidemiology (S.H.), UCLA Fielding School of Public Health, Los Angeles, CA; Division of Preventive Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry & Behavioral Medicine (S.R.R.), Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics, Gerontology, and Palliative Care (A.H.S.), Department of Medicine, University of California, San Diego, La Jolla.
Aladdin H ShadyabFrom the Division of Epidemiology (S.N., L.K.M., A.H.S.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla; Kaiser Permanente Washington Health Research Institute (L.K.M.), Seattle, WA; Departments of Internal Medicine and Biostatistics and Data Science (M.A.E.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (E.A.W.), Gillings School of Global Public Health; Department of Medicine (E.A.W.), School of Medicine, University of North Carolina, Chapel Hill; Altos Labs (A.L., S.H.), San Diego, CA; Department of Epidemiology (S.H.), UCLA Fielding School of Public Health, Los Angeles, CA; Division of Preventive Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry & Behavioral Medicine (S.R.R.), Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics, Gerontology, and Palliative Care (A.H.S.), Department of Medicine, University of California, San Diego, La Jolla.ORCID 0000-0002-9693-0522
Funding
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI THOMAS COSTIN REGISTER · 2021 to 2026
$24.3MEpigenetic Aging Biomarkers of Mild Cognitive Impairment, Alzheimer's Disease and Related Dementias, and Brain AgingRF1AG074345 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHADYAB, ALADDIN · 2021 to 2021
$2.1MEpigenetic Aging Biomarkers of Mild Cognitive Impairment, Alzheimer's Disease and Related Dementias, and Brain AgingR01AG074345 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHADYAB, ALADDIN · 2024 to 2025
$1.1MPlasma proteomic signatures of physical activity and Alzheimer's disease and related dementiasK99AG082863 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, STEVE · 2023 to 2024
$206kNIA NIH HHS K99 AG082863NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG074345NIA NIH HHS RF1 AG074345
Abstract
BACKGROUND AND
objectivesEpigenetic age estimators indicating faster/slower biological aging vs chronological age independently associate with several age-related outcomes; however, longitudinal associations with cognitive function are understudied. We examined associations of epigenetic age estimators with cognitive function measured annually.
methodsThis longitudinal study consisted of older women enrolled in the Women's Health Initiative Memory Study with DNA methylation (DNAm) collected at baseline (1995-1998) from 3 ancillary studies and were followed up to 13 years. Global cognitive function was measured annually by Modified Mini-Mental State Examination (3MS; baseline-2007) and by modified Telephone Interview for Cognitive Status (TICS-m, 2008-2021). We calculated 5 epigenetic age estimators: extrinsic AgeAccel, intrinsic AgeAccel, AgeAccelPheno, AgeAccelGrim2, Dunedin Pace of Aging Calculated From the Epigenome (DunedinPACE), and AgeAccelGrim2 components (DNA-based plasma protein surrogates). We estimated longitudinal epigenetic age estimator-cognitive function associations using linear mixed-effects models containing age, education, race or ethnicity, and subsequently alcohol, smoking, body mass index, and comorbidities. We examined effect modification by
resultsA total of 795 participants were enrolled. The mean baseline age was 70.8 ± 4 years (10.7% Black, 3.9% Hispanic or Latina, 85.4% White), A 1-SD (0.12) increment in DunedinPACE associated with faster annual declines in TICS-m scores in minimally adjusted (β = -0.118, 95% CI -0.202 to -0.034; DISCUSSION: Higher DunedinPACE associated with faster declines in TICS-m and 3MS scores among
Indexed as
AgingCognitionDNA MethylationEpigenesis, GeneticWomen's HealthAgedAged, 80 and overFemaleHumansLongitudinal StudiesMemoryMiddle Aged
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