Evidence map›Paper›PMID 38857182›Full record

ArticleAnalytical chemistry2024

Toward Next-Generation Molecular Imaging with a Clinical Low-Field (0.064 T) Point-of-Care MRI Scanner.

Nadiya Iqbal, Drew O Brittin, Praveen J Daluwathumullagamage, Md Shahabuddin Alam, Ishani M Senanayake, A Tobi Gafar, Zahid Siraj, Anthony Petrilla, Margaret Pugh, Brockton Tonazzi and 7 more

Abstract read
In one paragraph

Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Magnetic resonance imaging.Science advances · 2026
    Review
  3. Article
  4. Ultra-low fieldCommunications chemistry · 2026
    Article
  5. The journal of physical chemistry. B · 2025
    Article
  6. The journal of physical chemistry. B · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nadiya IqbalSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States.
Drew O BrittinSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States.
Praveen J DaluwathumullagamageSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States.
Md Shahabuddin AlamSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States.
Ishani M SenanayakeSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States.
A Tobi GafarSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States.
Zahid SirajSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States.
Anthony PetrillaSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States.
Margaret PughSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States.
Brockton TonazziSchool of Medicine, Southern Illinois University, Carbondale, Illinois 62901, United States.
Sudarshan RagunathanHyperfine Inc., Guilford, Connecticut 06437, United States.
Megan E PoormanHyperfine Inc., Guilford, Connecticut 06437, United States.
Laura SacolickHyperfine Inc., Guilford, Connecticut 06437, United States.
Thomas TheisDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0001-6779-9978
Matthew S RosenA.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, United States.
Eduard Y ChekmenevDepartment of Chemistry, Integrative Biosciences (IBio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202, United States.ORCID 0000-0002-8745-8801
Boyd M GoodsonSchool of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States.ORCID 0000-0001-6079-5077

Funding

Plug-and-play Hyperpolarized MRI of Metabolism on Clinical ScannersR01EB034197 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Eduard Chekmenev, Matthew Scot Rosen · 2024 to 2026
$1.8M
Molecular MRI of Brain Metabolism Enabled by Long-Lived Spin StatesR01EB029829 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2020 to 2020
$807k
Hyperpolarized Diethyl Ether for Sub-second Pulmonary MRIR21HL154032 · NHLBI · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2020 to 2021
$419k
Rapid low-cost production of contrast agents for metabolic imagingR21EB033872 · NIBIB · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2023 to 2024
$415k
NHLBI NIH HHS R21 HL154032NIBIB NIH HHS R01 EB029829NIBIB NIH HHS R01 EB034197NIBIB NIH HHS R21 EB033872
6 · The paper itself

Abstract

Low-field (LF) MRI promises soft-tissue imaging without the expensive, immobile magnets of clinical scanners but generally suffers from limited detection sensitivity and contrast. The sensitivity boost provided by hyperpolarization can thus be highly synergistic with LF MRI. Initial efforts to integrate a continuous-bubbling SABRE (signal amplification by reversible exchange) hyperpolarization setup with a portable, point-of-care 64 mT clinical MRI scanner are reported. Results from

Indexed as

Magnetic Resonance ImagingMolecular ImagingNiacinamidePoint-of-Care SystemsPyrazinesHumansNiacinamidePyrazines

Identifiers

PMID38857182
PMCPMC11416731

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.