Evidence map›Paper›PMID 38856882›Full record

ArticleJournal of cardiovascular translational research2024

CRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications.

Linzi Zeng, Shalaimaiti Shali, Yabiao Gao, Xingchen Du, Xiaoxia Zhu, Lin Li, Yuxiang Dai, Ping Zhou

Abstract read
In one paragraph

Article in Journal of cardiovascular translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Linzi Zeng *Department of Physiology and Pathophysiology of School of Basic Medical Sciences, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Shalaimaiti Shali *Department of Physiology and Pathophysiology of School of Basic Medical Sciences, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. shali@zs-hospital.sh.cn.ORCID 0000-0001-6842-3956
Yabiao Gao *Department of Physiology and Pathophysiology of School of Basic Medical Sciences, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xingchen DuDivision of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoxia ZhuDivision of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China.
Lin LiDepartment of Nephrology, Shanghai Changzheng Hospital, The Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Yuxiang DaiDepartment of Physiology and Pathophysiology of School of Basic Medical Sciences, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. dai.yuxiang@zs-hospital.sh.cn.
Ping ZhouDepartment of Physiology and Pathophysiology of School of Basic Medical Sciences, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. zping@shmu.edu.cn.

Funding

Clinical Research Plan of Shanghai Hospital Development Center SHDC2020CR1007AMunicipal Key Clinical Specialty SHSLCZDZK01701National Natural Science Foundation of China 82200490Program of Shanghai Academic Research Leader 22XD1423300Shanghai Clinical Research Center for Interventional Medicine 19MC1910300Shanghai Municipal Health Commission Emerging Cross-fields Programme 2022JC012Shanghai Science and Technology Commission Experimental Animal Project 19140900900
6 · The paper itself

Abstract

Hyperuricemia is a common metabolic disorder with severe complications. We aimed to develop a mouse model for spontaneous hyperuricemia. Uox

Indexed as

AllopurinolCRISPR-Cas SystemsDisease Models, AnimalHyperuricemiaMice, Inbred C57BLMice, KnockoutPhenotypeUric AcidAnimalsBiomarkersGene DeletionGenetic Predisposition to DiseaseGout SuppressantsKidneyMaleRenal InsufficiencyAllopurinolBiomarkersGout SuppressantsUrate OxidaseUric AcidC57BL/6JCRISPR/Cas9HyperuricemiaMouse modelUrate oxidase

Identifiers

PMID38856882
PMCPMC11635051

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.