SynthesisAnnals of surgical oncology2024
Frailty Increases Morbidity and Mortality in Patients Undergoing Oncological Liver Resections: A Systematic Review and Meta-analysis.
Synthesis in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of frailty on overall survival and complications in patients with prostate cancer: a systematic review and meta-analysis.International urology and nephrology · 2026Pooled it
- Association of surgical strategy guided by Wu's classification with surgical outcomes in left-sided hepatocellular carcinoma patients with frailty.Surgical endoscopy · 2026Article
- Combined Impact of Sarcopenia and Low Visceral Adiposity on Postoperative Outcomes and Survival After Esophagectomy for Esophageal Cancer.Annals of surgical oncology · 2026Article
- Predictors of Postoperative Morbidity in Hepatic Hemangioma Surgery: A Single-Center Experience.Medicina (Kaunas, Lithuania) · 2026Article
- The National Clinical Database Risk Calculator and the 5-Item Modified Frailty Index Predict the Development of Postoperative Delirium After Surgery for Hepatocellular Carcinoma.Annals of gastroenterological surgery · 2026Article
- Surgical Resection of a Giant Hepatocellular Carcinoma in an 89-Year-Old Patient with Multiple Comorbidities: The Role of Frailty Assessment and Preoperative Optimisation-A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- Predicting Frailty Trajectories Using Interpretable Machine Learning Among Older Adults Following Hip Surgery: Prospective Longitudinal Study.JMIR aging · 2026Observational
- Frailty in hepatobiliary and pancreatic (HBP) surgery: a narrative review toward an HBP-specific, implementation-oriented framework.Gland surgery · 2026Review
- Hepatectomy for Hepatocellular Carcinoma in Elderly Patients: Perioperative Outcomes in the Modern Minimally Invasive Era.Journal of clinical medicine · 2026Article
- Radiomics of portal-phase ring enhancement: a novel imaging biomarker for bevacizumab response associated with overall survival rates. It might help with surgical decision-making in colorectal liver metastases?Updates in surgery · 2026Article
- Real-World Results of Curative Open Colorectal Cancer Surgery in Octogenarians: Long-Term Survival Despite High Frailty Burden.Medical sciences (Basel, Switzerland) · 2026Observational
- CT-defined sarcopenia as a predictive factor in patients undergoing portal vein embolization: a systematic review and meta-analysis.Translational gastroenterology and hepatology · 2026Article
- Individualized Risk Prediction of Medical Postoperative Complications After Oncologic Hepatectomy: A Nomogram-Based Approach.Medical sciences (Basel, Switzerland) · 2025Observational
- Should We Fear the Frail? A Review on the Impact of Frailty on Liver Surgery.Medical sciences (Basel, Switzerland) · 2025Review
- Nutritional status and frailty in elderly patients undergoing major abdominal surgery for upper gastrointestinal tumors: a single-center prospective observational study.Irish journal of medical science · 2025Observational
- Frailty Predicts Mortality and Procedural Performance in Patients With Non-Variceal Upper Gastrointestinal Bleeding.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Is Frailty Associated with Worse Outcomes After Major Liver Surgery? An Observational Case-Control Study.Diagnostics (Basel, Switzerland) · 2025Article
- [Multimorbidity in liver surgery].Chirurgie (Heidelberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsidered to reflect a patients' biological age, frailty is a new syndrome shown to predict surgical outcomes in elderly patients. In view of the increasing age at which patients are proposed oncological liver surgery and the morbidity associated with it, we attempted to perform a systematic review and meta-analysis to compare morbidity and mortality between frail and nonfrail patients after liver resections.
methodsThe study was registered with PROSPERO. A systematic search of PubMed and EMBASE databases was performed for all comparative studies examining surgical outcomes after liver resections between frail and nonfrail patients.
resultsTen studies were included based on the selection criteria with a total of 71,102 patients, split into two groups: frail (n = 17,167) and the control group (n = 53,928). There were more elderly patients with a lower preoperative albumin level in the frail group (p = 0.02, p = 0.001). Frail patients showed higher rates of morbidity with more major complications and a higher incidence of postoperative liver failure (p < 0.001). Mortality (p < 0.001) and readmission rate (p = 0.021) also was higher in frail patients.
conclusionsFrailty seems to be a solid predictive risk factor of morbidity and mortality after liver surgery and should be considered a selection criterion for liver surgery in at-risk patients.
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