ArticleEuropean radiology2024
In vitro blood sample assessment: investigating correlation of laboratory hemoglobin and spectral properties of dual-energy CT measurements (ρ/Z).
Article in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Experimental Characterisation of Differently Composed Thrombus Entities with Spectral-Detector-CT.Neurology international · 2026Article
- Evaluation of anemia in non-enhanced and contrast-enhanced dual-energy CT using electron density imaging.PloS one · 2026Article
- Dual- energy CT versus single-energy CT for estimation of hematocrit and hemoglobin in the brain: an in vivo analysis.Neuroradiology · 2025Article
- Performance comparison of dual-layer detector CT parameters from different blood vessels in the detection of anemia.Quantitative imaging in medicine and surgery · 2025Article
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6 authors.
Funding
Abstract
objectivesOur study comprised a single-center retrospective in vitro correlation between spectral properties, namely ρ/Z values, derived from scanning blood samples using dual-energy computed tomography (DECT) with the corresponding laboratory hemoglobin/hematocrit (Hb/Hct) levels and assessed the potential in anemia-detection.
methodsDECT of 813 patient blood samples from 465 women and 348 men was conducted using a standardized scan protocol. Electron density relative to water (ρ or rho), effective atomic number (Z
resultsPositive correlation with the Hb/Hct was shown for ρ (r-values 0.37-0.49) and attenuation (r-values 0.59-0.83) while no correlation was observed for Z
conclusionIn summary, our study investigated the correlation between DECT measurements and Hb/Hct levels, emphasizing novel aspects of ρ and Z CLINICAL RELEVANCE STATEMENT: By scanning multiple blood samples with dual-energy CT scans and comparing the measurements with standard laboratory blood tests, we were able to underscore the potential of CT-based anemia detection and its advantages in clinical practice. KEY POINTS: Prior in vivo studies have found a correlation between aortic blood pool and measured hemoglobin and hematocrit. Hemoglobin and hematocrit correlated with electron density relative to water and attenuation but not Z
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