Evidence map›Paper›PMID 38856764›Full record

ArticlePsychopharmacology2024

Regulator of G protein signaling 6 (RGS6) in dopamine neurons promotes EtOH seeking, behavioral reward, and susceptibility to relapse.

Mackenzie M Spicer, Matthew A Weber, Zili Luo, Jianqi Yang, Nandakumar S Narayanan, Rory A Fisher

Abstract read
In one paragraph

Article in Psychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Mackenzie M SpicerDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 51 Newton Rd. BSB 2-512, Iowa City, IA, 52242, USA.
Matthew A WeberIowa Neuroscience Institute, University of Iowa Carver College of Medicine, 169 Newton Rd., Iowa City, IA, 52242, USA.
Zili LuoDepartment of Pediatrics, University of Iowa Carver College of Medicine, 200 Hawkins Dr., Iowa City, IA, 52242, USA.
Jianqi YangDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 51 Newton Rd. BSB 2-512, Iowa City, IA, 52242, USA.
Nandakumar S NarayananIowa Neuroscience Institute, University of Iowa Carver College of Medicine, 169 Newton Rd., Iowa City, IA, 52242, USA.
Rory A FisherDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 51 Newton Rd. BSB 2-512, Iowa City, IA, 52242, USA. rory-fisher@uiowa.edu.ORCID http://orcid.org/0000-0003-3108-4836

Funding

RGS6 in mesolimbic circuits as a therapeutic target for alcohol use disordersR01AA025919 · NIAAA · UNIVERSITY OF IOWA · PI FISHER, RORY A. · 2018 to 2022
$2.8M
VTA dopamine neurons and cognitive symptoms of Parkinson’s diseaseR01NS120987 · NINDS · UNIVERSITY OF IOWA · PI NARAYANAN, NANDAKUMAR · 2021 to 2025
$2.0M
NIAAA NIH HHS R01 AA025919NIH HHS AA025919NIH HHS AA025919-03S1NIH HHS AA025919-05S1NINDS NIH HHS R01 NS120987
6 · The paper itself

Abstract

Mesolimbic dopamine (DA) transmission is believed to play a critical role in mediating reward responses to drugs of abuse, including alcohol (EtOH). The neurobiological mechanisms underlying EtOH-seeking behavior and dependence are not fully understood, and abstinence remains the only effective way to prevent alcohol use disorders (AUDs). Here, we developed novel RGS6

Indexed as

Dopaminergic NeuronsDrug-Seeking BehaviorEthanolRewardRGS ProteinsVentral Tegmental AreaAlcohol DrinkingAlcoholismAnimalsDopamine Plasma Membrane Transport ProteinsFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutDopamine Plasma Membrane Transport ProteinsEthanolRGS6 protein, humanRgs6 protein, mouseRGS ProteinsAlcohol use disorderBehavioral rewardConditioned place preferenceDopamineG protein signalingMesolimbic circuitRelapseRGS6Ventral tegmental area (VTA)

Identifiers

PMID38856764
PMCPMC11518640

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.