Evidence map›Paper›PMID 38856715›Full record

ArticleeLife2024

Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival.

Jongkyun Kang, Guodong Huang, Long Ma, Youren Tong, Anu Shahapal, Phoenix Chen, Jie Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jongkyun Kang *Department of Neurology, Brigham and Women's Hospital, Boston, United States.
Guodong Huang *Department of Neurology, Brigham and Women's Hospital, Boston, United States.
Long MaDepartment of Neurology, Brigham and Women's Hospital, Boston, United States.
Youren TongDepartment of Neurology, Brigham and Women's Hospital, Boston, United States.
Anu ShahapalDepartment of Neurology, Brigham and Women's Hospital, Boston, United States.
Phoenix ChenDepartment of Neurology, Brigham and Women's Hospital, Boston, United States.
Jie ShenDepartment of Neurology, Brigham and Women's Hospital, Boston, United States.ORCID https://orcid.org/0000-0003-1160-7118

Funding

Mouse CoreP50NS094733 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI SHEN, JIE · 2015 to 2020
$7.1M
LRRK in Autophagy Function and Dopaminergic Neuron SurvivalR37NS071251 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI SHEN, JIE · 2015 to 2021
$4.5M
NIH HHS P50NS094733NIH HHS R37NS071251NINDS NIH HHS P50 NS094733NINDS NIH HHS R37 NS071251
6 · The paper itself

Abstract

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease (PD). However, whether LRRK2 mutations cause PD and degeneration of dopaminergic (DA) neurons via a toxic gain-of-function or a loss-of-function mechanism is unresolved and has pivotal implications for LRRK2-based PD therapies. In this study, we investigate whether

Indexed as

Cell SurvivalDopaminergic NeuronsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Mice, KnockoutAnimalsApoptosisMiceParkinson DiseaseProtein Serine-Threonine KinasesLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lrrk1 protein, mouseLrrk2 protein, mouseProtein Serine-Threonine Kinasesconditional knock-out micedopaminergic neuronLRRK1LRRK2mouseneuroscienceParkinson's diseasesubstantia nigra pars compacta

Identifiers

PMID38856715
PMCPMC11164531

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.