Evidence map›Paper›PMID 38856149›Full record

ArticleGlia2024

Astrocyte coverage of excitatory synapses correlates to measures of synapse structure and function in ferret primary visual cortex.

Connon I Thomas, Melissa A Ryan, Micaiah C McNabb, Naomi Kamasawa, Benjamin Scholl

Abstract read
In one paragraph

Article in Glia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Reward Expectation Reduces Representational Drift in the Hippocampus.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Connon I ThomasElectron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, Jupiter, Florida, USA.ORCID 0000-0003-0995-9667
Melissa A RyanElectron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, Jupiter, Florida, USA.ORCID 0000-0002-0468-9525
Micaiah C McNabbElectron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, Jupiter, Florida, USA.ORCID 0000-0002-3307-1396
Naomi KamasawaElectron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, Jupiter, Florida, USA.ORCID 0000-0002-8926-5309
Benjamin SchollDepartment of Physiology and Biophysics, University of Colorado Denver, Aurora, Colorado, USA.ORCID 0000-0002-9578-7234

Funding

CRCNS: Linking Synaptic Populations and Computation Using Statistical MechanicsR01NS135763 · NINDS · UNIVERSITY OF ROCHESTER · PI Krishnan Padmanabhan · 2023 to 2026
$984k
PRINCIPLES OF PRESYNAPTIC NETWORKS FOR SINGLE LAYER 2/3 NEURONS IN FERRET VISUAL CORTEXR00EY031137 · NEI · UNIVERSITY OF PENNSYLVANIA · PI SCHOLL, BENJAMIN KYLE · 2021 to 2023
$967k
Max Planck Florida Institute for NeuroscienceNEI NIH HHS R00 EY031137NIH HHS R00 EY031137NINDS NIH HHS R01 NS135763
6 · The paper itself

Abstract

Most excitatory synapses in the mammalian brain are contacted or ensheathed by astrocyte processes, forming tripartite synapses. Astrocytes are thought to be critical regulators of the structural and functional dynamics of synapses. While the degree of synaptic coverage by astrocytes is known to vary across brain regions and animal species, the reason for and implications of this variability remains unknown. Further, how astrocyte coverage of synapses relates to in vivo functional properties of individual synapses has not been investigated. Here, we characterized astrocyte coverage of synapses of pyramidal neurons in the ferret visual cortex and, using correlative light and electron microscopy, examined their relationship to synaptic strength and sensory-evoked Ca

Indexed as

AstrocytesFerretsPrimary Visual CortexSynapsesAnimalsCalciumExcitatory Postsynaptic PotentialsFemaleMalePhotic StimulationPyramidal CellsVisual CortexCalciumastrocytescalcium imagingcorrelative microscopyin vivo microscopystructure and functiontripartite synapsevisual cortexvolume electron microscopy

Identifiers

PMID38856149
PMCPMC11324397

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.