Evidence map›Paper›PMID 38855783›Full record

ArticleJournal of clinical medicine research2024

Immune Checkpoints Receptors Expression of Macrophage/Monocytes in Response to Acute Viral Respiratory Infection.

Asmaa Zahran, Hosni A Hussein, Ali A Thabet, Mohamed R Izzaldin, Ahmed A Wardany, Ali Sobhy, Mohamed A Bashir, Magdy M Afifi, Wageeh A Ali, Amal Rayan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Asmaa ZahranDepartment of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Hosni A HusseinDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt.
Ali A ThabetDepartment of Zoology, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt.
Mohamed R IzzaldinDepartment of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Assiut 71524, Egypt.
Ahmed A WardanyDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt.
Ali SobhyDepartment of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Assiut 71524, Egypt.
Mohamed A BashirDepartment of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Assiut 71524, Egypt.
Magdy M AfifiDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
Wageeh A AliDiagnostic and Interventional Radiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Amal RayanDepartment of Clinical Oncology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Khaled SaadDepartment of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.ORCID https://orcid.org/0000-0002-8473-6116
Mohammad Gamal KhalafDepartment of Chest Diseases, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mahmoud Elsaeed AhmedDepartment of Chest Diseases, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Noha G SayedDepartment of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We aimed to monitor the phenotypic changes in macrophages and their polarization in patients with acute viral respiratory diseases, including coronavirus disease diagnosis, focusing on the variations in the percentages of macrophages and monocytes and their sub-populations in those patients compared to healthy control. Moreover, we defined the correlation between macrophage subtypes and some inflammatory indices. Methods: Twenty-seven patients with clinical and radiologic diagnosis of acute viral respiratory infection admitted in Al-Azhar and Assiut University hospitals were recruited. Fresh peripheral blood samples were collected from all patients and healthy controls for flow cytometric analysis using BD FACSCanto II analyzer equipped with three lasers. Results: Compared to healthy controls, accumulation of cluster of differentiation (CD)11B Conclusion: The examination of clinical specimens obtained from patients with signs of acute respiratory viral infection showed the role of the macrophage in the immune response. Dysfunction in macrophages results in heightened immune activity and inflammation, which plays a role in the progression of viral diseases and the emergence of accompanying health issues. This malfunction in macrophages is a common characteristic seen in various viruses, making it a promising focus for antiviral therapies with broad applicability. The immune checkpoint could be a target for immune modulation in patients with severe symptoms.

Indexed as

Acute respiratory viral infectionCD273+ M1CD273+ M2CD274+ M1CD274+ M2Macrophages

Identifiers

PMID38855783
PMCPMC11161185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.