ReviewInternational journal of nanomedicine2024
Prosthetic Metals: Release, Metabolism and Toxicity.
Review in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Multifunctional Metal-Coordinated Hydrogels: Controlled Synthesis and Advances in Anti-Inflammatory, Anticancer, and Antibacterial Applications.ACS omega · 2026Review
- Knee arthroplasty failure is associated with significant systemic multimetal exposure.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Systemic Cobalt Toxicity Secondary to Tibial Component Malpositioning in Bilateral Primary Total Knee Arthroplasties.Arthroplasty today · 2026Article
- Magnesium ion implantation enhances the osseointegration and vascularization of 3D-Printed CoCrMo alloy scaffolds for load-bearing orthopedic applications.Bioactive materials · 2026Article
- Delayed Ischemic Hepatocellular Injury Following Cemented Total Hip Arthroplasty: A Case Report Within the Spectrum of Bone Cement Implantation Syndrome.Life (Basel, Switzerland) · 2026Article
- Morphological and Cytotoxic Effects of Metal Salts on Osteoblast Cells in Three-Dimensional Spheroidal Cultures.Journal of toxicology · 2026Article
- Ferroptosis in orthopedic implant integration after oncologic surgery.Frontiers in oncology · 2026Review
- Kinetics and Fluid-Specific Behavior of Metal Ions After Hip Replacement.Bioengineering (Basel, Switzerland) · 2025Article
- Laser Remelting of Biocompatible Ti-Based Glass-Forming Alloys: Microstructure, Mechanical Properties, and Cytotoxicity.Materials (Basel, Switzerland) · 2025Article
- Bone-Ti-Alloy Interaction in Hip Arthroplasty of Patients with Diabetes, Dyslipidaemia, and Kidney Dysfunction: Three Case Reports and Brief Review.Medicina (Kaunas, Lithuania) · 2025Review
- Impact of Intramedullary Implants on Metallic Element Homeostasis in Children with Forearm Fractures.Journal of clinical medicine · 2025Article
- 2050: An Arthroplasty Odyssey.Healthcare (Basel, Switzerland) · 2025Article
- Porcelain Fused to Titanium-Advantages and Challenges.Dentistry journal · 2025Review
- Peptide-based inflammation-responsive implant coating sequentially regulates bone regeneration to enhance interfacial osseointegration.Nature communications · 2025Article
- Study of the Structure and Mechanical Properties of Ti-38Zr-11Nb Alloy.Journal of functional biomaterials · 2025Article
- Evaluation of bacterial adherence and biofilm development on an anodized stainless-steel surface for the prevention of osteosynthesis-associated infections.Journal of bone and joint infection · 2025Article
- Antimicrobial activity of copper-nickel coated door handles: a blinded, randomized controlled study in a clinical setting.GMS hygiene and infection control · 2025Article
- Salivary Chromium and Cobalt Concentrations in Patients with Dental Metallic Restorations-A Pilot Study.Dentistry journal · 2024Article
- Association between metal implants and urinary chromium levels in US adults: a cross-sectional study from NHANES.Scientific reports · 2024Article
- Association between metallic implants and stroke in US adults from NHANES 2015-2023 a cross-sectional study.Frontiers in aging neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of metallic joint prostheses has been ongoing for more than a century alongside advancements in hip and knee arthroplasty. Among the materials utilized, the Cobalt-Chromium-Molybdenum (Co-Cr-Mo) and Titanium-Aluminum-Vanadium (Ti-Al-V) alloys are predominant in joint prosthesis construction, predominantly due to their commendable biocompatibility, mechanical strength, and corrosion resistance. Nonetheless, over time, the physical wear, electrochemical corrosion, and inflammation induced by these alloys that occur post-implantation can cause the release of various metallic components. The released metals can then flow and metabolize in vivo, subsequently causing potential local or systemic harm. This review first details joint prosthesis development and acknowledges the release of prosthetic metals. Second, we outline the metallic concentration, biodistribution, and elimination pathways of the released prosthetic metals. Lastly, we discuss the possible organ, cellular, critical biomolecules, and significant signaling pathway toxicities and adverse effects that arise from exposure to these metals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.