ArticleBiomedical optics express2024
Theoretical and experimental determination of the confocal function of OCT systems for accurate calculation of sample optical properties.
Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Monte Carlo OCT simulations investigating the effect of multiple scattered light on OCT-based attenuation coefficient quantification.Biomedical optics express · 2026Article
- Hybrid particle-wave Monte Carlo OCT simulation method provides a three orders of magnitude improvement in efficiency.Biomedical optics express · 2026Article
- Achieving High-Precision Attenuation Coefficient Measurement in Optical Coherence Tomography.Journal of biophotonics · 2025Article
- Basis function model to extract the combined confocal and fall-off function from multiple optical coherence tomography A-scans.Journal of biomedical optics · 2025Article
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Authors and funding
4 authors.
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Abstract
The attenuation coefficient of biological tissue could serve as an indicator of structural and functional changes related to the onset or progression of disease. Optical coherence tomography (OCT) provides cross sectional images of tissue up to a depth of a few millimeters, based on the local backscatter properties. The OCT intensity also depends on the confocal function, which needs to be characterised to determine correctly the exponential decay of the intensity based on Lambert-Beer. We present a model for the confocal function in scattering media based on the illumination with a Gaussian beam and the power transfer into a single mode fibre (SMF) of the backscattered light for an incoherently back scattered Gaussian beam using the Huygens-Fresnel principle and compare that model with the reflection from a mirror. We find that, contrary to previous literature, the confocal functions characterised by the Rayleigh range in the two models are identical. Extensive OCT focus series measurements on a mirror, Spectralon and Intralipid dilutions confirm our model, and show that for highly scattering samples the confocal function characterised by the Rayleigh range becomes depth dependent. From the diluted Intralipid measurements the attenuation coefficients are extracted using a singly scatter model that includes the previously established confocal function. The extracted attenuation coefficients were in good agreement for weakly scattering samples (
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