ReviewJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2024
The connection between hypertension and diabetes and their role in heart and kidney disease development.
Review in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of intensive versus standard blood pressure control on cardiovascular outcomes: a meta-analysis of randomized controlled trials.Annals of medicine · 2026Pooled it
- Blood pressure targets for hypertension in people with diabetes mellitus.The Cochrane database of systematic reviews · 2026Pooled it
- The link between hyperuricemia and diabetes: insights from a quantitative analysis of scientific literature.Frontiers in endocrinology · 2024Pooled it
- Multilevel analysis of noncommunicable diseases and associated factors among Ethiopian adults: evidence from the 2024 STEPS survey.Tropical medicine and health · 2026Article
- Article
- Molecular biology of vascular bioenergetics rewiring: Mitochondrial protective mechanisms of Piper retrofractum in hypertension and oxidative injury.Molecular biology reports · 2026Review
- Association of Door-to-Balloon Delay with Complications and Length of Hospital Stays in Patients with ST-Elevation Myocardial Infarction.Journal of clinical medicine · 2026Article
- Modeling variable interactions using Bayesian networks to identify direct predictors of radiation-induced optic neuropathy after proton therapy: implications for personalized toxicity risk stratification.Physics in medicine and biology · 2026Article
- Exploring Core Symptoms and Symptom Clusters Among Older Adults with Hypertension-Diabetes Comorbidity: A Network Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Cardiorenal Protective Effects of Finerenone in Patients with Type 2 Diabetes Mellitus.Archives of internal medicine research · 2026Article
- A Qualitative Study to Explore the Influence of Condition Prioritisation in People With Coexisting Diabetes and Hypertension on Medication Adherence.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Article
- Valorization of Goat Blood: Hydrolysate Production, Identification, Stability, and Bioavailability upon Gastrointestinal Digestion of Peptides with Dual ACE and DPP-IV Inhibitory Properties.Foods (Basel, Switzerland) · 2026Article
- Impact of Patient Demographics and Cardiovascular Risk Factors on Percutaneous Coronary Intervention Outcomes.Cureus · 2026Article
- Diabetes mellitus, TB, and HIV multi-morbidities among adults in Uganda.Public health action · 2026Article
- Review
- Prevalence and determinants of multimorbidity among resettled Bhutanese older adults in Ohio, USA.BMC public health · 2026Article
- Identification of bacterial key genes and therapeutic targets in hypertensive patients with type 2 diabetes through bioinformatics analysis.Scientific reports · 2026Article
- Post-COVID Syndrome in Patients With Comorbid Hypertension or Diabetes: A Narrative Review of Long-Term Outcomes.Cureus · 2026Review
- Modulating Renal Fibrosis: The Emerging Role of Hepatocyte Growth Factor.International journal of nephrology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension and diabetes are two common metabolic disorders that often coexist in the same individual. Their concurrence increases the risk of cardiovascular disease, renal dysfunction, and other complications. Cardiovascular disease is the primary cause of morbidity and mortality in individuals with diabetes, and hypertension further aggravates this condition. Interestingly, hypertension and diabetes share several common pathophysiological mechanisms including insulin resistance, vascular inflammation, endothelial dysfunction, obesity, and oxidative stress suggesting a cross-talk between these two conditions that could potentially contribute to the development of other human diseases. Effective management of diabetes should include a multifaceted approach that addresses not only glycemic control but also blood pressure (BP) and lipid control. Treatment plans should be individualized to each patient's needs and should involve a combination of lifestyle modifications and medications to achieve optimal control. With the availability of newer antidiabetic medications such as SGLT inhibitors and GLP1 receptor agonists, it is crucial to consider their potential to reduce BP, enhance kidney function, and lower the risk of cardiovascular diseases when initiating treatment for glycemic control. A more profound comprehension of the shared underlying mechanisms between these conditions could pave the way for the development of innovative therapeutic approaches to tackle them. Our review offers an in-depth analysis of the literature, providing a holistic view of the mechanisms underlying diabetes-hypertension comorbidity and its implications on heart and kidney diseases. The present article concludes by discussing current approaches for managing hypertensive diabetic patients to create a set of comprehensive individualized recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.