Nanometer scale difference in myofilament lattice structure of muscle alter muscle function in a spatially explicit model.

Travis Tune, Simon Sponberg

Abstract readPreprint

In one paragraph

Article in ArXiv, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Updated by
Nanometer scale difference in myofilament lattice structure of muscle alters muscle function in a spatially explicit model.2025

5 · Who and what money

Authors and funding

2 authors.

Travis TuneSchool of Physics, Georgia Institute of Technology, Atlanta, Georgia, USA.

Simon SponbergSchool of Physics, Georgia Institute of Technology, Atlanta, Georgia, USA.

Funding

UW Center for Translational Muscle Research (Overall Application)P30AR074990 · NIAMS · UNIVERSITY OF WASHINGTON · PI MICHAEL REGNIER · 2019 to 2026

$7.5M

Uncovering The Mechanogenomic Basis For Cardiac PlasticityR01HL142624 · NHLBI · UNIVERSITY OF WASHINGTON · PI Jennifer Michelle Davis · 2018 to 2026

$3.8M

Experimental and Computational Studies in Genetic CardiomyopathiesR01HL157169 · NHLBI · UNIVERSITY OF WASHINGTON · PI Farid Moussavi-Harami · 2022 to 2026

$3.3M

NHLBI NIH HHS R01 HL142624NHLBI NIH HHS R01 HL157169NIAMS NIH HHS P30 AR074990

6 · The paper itself

Abstract

Crossbridge binding, state transitions, and force in active muscle is dependent on the radial spacing between the myosin-containing thick filament and the actin-containing thin filament in the filament lattice. This radial lattice spacing has been previously shown through spatially explicit modeling and experimental efforts to greatly affect quasi-static, isometric, force production in muscle. It has recently been suggested that this radial spacing might also be able to drive differences in mechanical function, or net work, under dynamic oscillations like those which occur in muscles

Identifiers

PMID38855552

PMCPMC11160890

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.