ArticleWorld journal of otorhinolaryngology - head and neck surgery2024
Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment: A longitudinal cohort study.
Article in World journal of otorhinolaryngology - head and neck surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Lost and Found: Is Olfactory Recovery More Promising After COVID-19 Than Other Causes, Even 2 Years Later?International forum of allergy & rhinology · 2026Article
- Recovery of Parosmia Preferentially Influences Longitudinal Improvement of Quality of Life in C19OD.International forum of allergy & rhinology · 2026Article
- Therapeutic Effects ofLife (Basel, Switzerland) · 2026Article
- Symptom Trajectories and Long-Term Sequelae of COVID-19: A Matched Case-Control Study with Population-Based Controls.Journal of clinical medicine · 2026Article
- Longitudinal evaluation of neurocognitive outcomes in a cohort with persistent post-COVID olfactory dysfunction.Scientific reports · 2026Article
- Prevalence of olfactory dysfunction among postpartum women and impact of SARS-CoV-2 infection during pregnancy.Chemical senses · 2025Article
- Olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs) in subjects after Covid-19 infection: single-center prospective study.Journal of applied biomedicine · 2024Article
- Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment: A longitudinal cohort study.World journal of otorhinolaryngology - head and neck surgery · 2024Article
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Authors and funding
12 authors.
Funding
Abstract
Objectives: Persistent olfactory dysfunction (OD) following loss of smell associated with SARS-CoV-2 infection is a major feature of long COVID. Perspectives on the prevalence of persistent OD predominantly rely on self-reported olfactory function. Few studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute recovery. Data anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of smell. This study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical OD. Methods: We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin' Sticks extended test at baseline and 1-year time points. Participants had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not available. Results: Baseline olfactory evaluation was completed by 122 participants, 53 of whom completed the 1-year follow-up assessment. Among participants presenting with perceived OD, 74.5% had confirmed psychophysical OD at baseline, with 55.1% at 1-year follow-up. Participants had reliable trends in self-rated versus psychophysically tested olfactory function at both time points. The total threshold, discrimination, and identification (TDI) score improved by +3.25 points in the cohort with psychophysical OD ( Conclusions: OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19, with many demonstrating lingering deficits at 1-year. Improvements in threshold, but not discrimination or identification, most significantly mediate improvement of total TDI score at follow-up.
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