Evidence map›Paper›PMID 38855184›Full record

ReviewTheranostics2024

Bioinspired cellular membrane-derived vesicles for mRNA delivery.

Xiao Xu, Limei Xu, Jingzhi Wang, Caining Wen, Jiang Xia, Yuanmin Zhang, Yujie Liang

Abstract readReview
In one paragraph

Review in Theranostics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
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  12. Round window membrane extracellular vesicles facilitate inner ear drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Biologics-based technologies for highly efficient and targeted RNA delivery.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  18. Exosomes in cartilage microenvironment regulation and cartilage repair.Frontiers in cell and developmental biology · 2025
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiao XuAffiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.
Limei XuAffiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.
Jingzhi WangAffiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.
Caining WenAffiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.
Jiang XiaDepartment of Chemistry, The Chinese University of Hong Kong, Hong Kong, China.
Yuanmin ZhangAffiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.
Yujie LiangAffiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid advancement of mRNA as vaccines and therapeutic agents in the biomedical field has sparked hope in the fight against untreatable diseases. Successful clinical application of mRNA therapeutics largely depends on the carriers. Recently, a new and exciting focus has emerged on natural cell-derived vesicles. These nanovesicles offer many functions, including enhanced drug delivery capabilities and immune evasion, thereby presenting a unique and promising platform for the effective and safe delivery of mRNA therapeutics. In this study, we summarize the characteristics and properties of biomimetic delivery systems for mRNA therapeutics. In particular, we discuss the unique features of cellular membrane-derived vesicles (CDVs) and the combination of synthetic nanovesicles with CDVs.

Indexed as

Drug Delivery SystemsRNA, MessengerAnimalsBiomimeticsCell MembraneDrug CarriersHumansDrug CarriersRNA, Messengercellular membrane-derived vesiclesexosomesextracellular vesiclemRNA deliverymRNA vaccine

Identifiers

PMID38855184
PMCPMC11155408

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.