Evidence map›Paper›PMID 38855156›Full record

ArticleWorld journal of gastroenterology2024

Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis.

Lian-Meng Huang, Ming-Jin Zhang

Abstract read
In one paragraph

Article in World journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lian-Meng HuangDepartment of General Surgery, The 901 Hospital of PLA, Hefei 230031, Anhui Province, China.
Ming-Jin ZhangDepartment of General Surgery, The 901 Hospital of PLA, Hefei 230031, Anhui Province, China. zhangmingjin2001@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe regulatory effects of

aimTo investigate the regulatory functions of

methodsWe analyzed genes' mRNA levels by quantitative real-time polymerase chain reaction. Expression levels of target proteins were detected by immunohistochemistry, ELISA, and Western blotting. We injected AGS cells into nude mice for the establishment of a xenograft tumor model and observed the occurrence and metastasis of GC. The degree of inflammatory infiltration in pulmonary nodes was observed through hematoxylin-eosin staining. Transwell and wound healing assays were performed for the evaluation of cell invasion and migration ability. Tube formation assay was used for detecting angiogenesis. M2-polarized macrophages were estimated by immunofluorescence and flow cytometry.

results

conclusion

Indexed as

Cancer-Associated FibroblastsGene Expression Regulation, NeoplasticKinesinsStomach NeoplasmsAnimalsCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionFemaleHumansMacrophagesMaleMiceMice, Inbred BALB CMice, NudeNeoplasm InvasivenessKIF26B protein, humanKinesinsCancer-associated fibroblastsGastric cancerImmunityKIF26BM2 polarization macrophageMetastasis

Identifiers

PMID38855156
PMCPMC11154681

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.