Evidence map›Paper›PMID 38855143›Full record

ArticleFrontiers in bioinformatics2024

Human cytokine and coronavirus nucleocapsid protein interactivity using large-scale virtual screens.

Phillip J Tomezsko, Colby T Ford, Avery E Meyer, Adam M Michaleas, Rafael Jaimes

Abstract read
In one paragraph

Article in Frontiers in bioinformatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. AI-based antibody design targeting recent H5N1 avian influenza strains.Computational and structural biotechnology journal · 2025
    Article
  4. Article
  5. Review
  6. PD-1 Targeted Antibody Discovery Using AI Protein Diffusion.Technology in cancer research & treatment
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Phillip J TomezskoMIT Lincoln Laboratory, Lexington, MA, United States.
Colby T FordTuple LLC, Charlotte, NC, United States.
Avery E MeyerMIT Lincoln Laboratory, Lexington, MA, United States.
Adam M MichaleasMIT Lincoln Laboratory, Lexington, MA, United States.
Rafael JaimesMIT Lincoln Laboratory, Lexington, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the interactions between SARS-CoV-2 and the human immune system is paramount to the characterization of novel variants as the virus co-evolves with the human host. In this study, we employed state-of-the-art molecular docking tools to conduct large-scale virtual screens, predicting the binding affinities between 64 human cytokines against 17 nucleocapsid proteins from six betacoronaviruses. Our comprehensive

Indexed as

AlphaFold2coronavirusdockingMERS- and SARS-CoVnucleocapsid (N) proteinOC43-CoVprotein-protein interaction (PPI)SARS-CoV-2

Identifiers

PMID38855143
PMCPMC11157076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.