Evidence map›Paper›PMID 38855125›Full record

ArticleInternational journal of mass spectrometry2023

Mass spectrometry characterization of antibodies at the intact and subunit levels: from targeted to large-scale analysis.

Jake T Kline, Rafael D Melani, Luca Fornelli

Abstract read
In one paragraph

Article in International journal of mass spectrometry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Deep Proteoform Sequencing with Top-Down Direct Mass Technology.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Top-Down and Middle-Down Mass Spectrometry of Antibodies.Molecular & cellular proteomics : MCP · 2025
    Review
  4. AsymmetricJournal of the American Chemical Society · 2024
    Article
  5. Article
  6. Top-down proteomics.Nature reviews. Methods primers · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jake T KlineDepartment of Biology, University of Oklahoma, Norman, Oklahoma 73019, United States.
Rafael D MelaniThermo Fisher Scientific, San Jose, California 95134, United States.
Luca FornelliDepartment of Biology, University of Oklahoma, Norman, Oklahoma 73019, United States.

Funding

A multi-level mass spectrometry pipeline for the analysis of whole proteoforms and their complexesR35GM147397 · NIGMS · UNIVERSITY OF OKLAHOMA · PI Luca Fornelli · 2022 to 2026
$1.9M
NIGMS NIH HHS R35 GM147397
6 · The paper itself

Abstract

Antibodies are one of the most formidable molecular weapons available to our immune system. Their high specificity against a target (antigen) and capability of triggering different immune responses (

Indexed as

antibodycharge detection mass spectrometryde novo sequencingelectron transfer dissociationIdeSIgGmiddle-downmonoclonalpolyclonaltop-downultraviolet photodissociation

Identifiers

PMID38855125
PMCPMC11160972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.