Evidence map›Paper›PMID 38855062›Full record

ArticleFrontiers in chemistry2024

Exploration of morpholine-thiophene hybrid thiosemicarbazones for the treatment of ureolytic bacterial infections via targeting urease enzyme: Synthesis, biochemical screening and computational analysis.

Rubina Munir, Sumera Zaib, Muhammad Zia-Ur-Rehman, Hira Javed, Ayesha Roohi, Muhammad Zaheer, Nabiha Fatima, Mashooq Ahmad Bhat, Imtiaz Khan

Abstract read
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In one paragraph

Article in Frontiers in chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Discovery ofFuture medicinal chemistry · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rubina MunirDepartment of Chemistry, Kinnaird College for Women, Lahore, Pakistan.
Sumera ZaibDepartment of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan.
Muhammad Zia-Ur-RehmanApplied Chemistry Research Centre, PCSIR Laboratories Complex, Lahore, Pakistan.
Hira JavedDepartment of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan.
Ayesha RoohiDepartment of Chemistry, Kinnaird College for Women, Lahore, Pakistan.
Muhammad ZaheerApplied Chemistry Research Centre, PCSIR Laboratories Complex, Lahore, Pakistan.
Nabiha FatimaDepartment of Chemistry, Kinnaird College for Women, Lahore, Pakistan.
Mashooq Ahmad BhatDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Imtiaz KhanDepartment of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An important component of the pathogenicity of potentially pathogenic bacteria in humans is the urease enzyme. In order to avoid the detrimental impact of ureolytic bacterial infections, the inhibition of urease enzyme appears to be an appealing approach. Therefore, in the current study, morpholine-thiophene hybrid thiosemicarbazone derivatives (

Indexed as

binding interactionsmorpholinepharmacokineticsthiophenethiosemicarbazoneurease

Identifiers

PMID38855062
PMCPMC11157103

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.