Evidence map›Paper›PMID 38855016›Full record

ArticleResults in chemistry2023

Cysteinyl leukotriene-like metabolites are generated in retinal pigment epithelial cells through glutathionylation/reduction of an oxidatively truncated fragment of arachidonate.

Mikhail Linetsky, Anshula Mondal, Si-Yang Liu, Abby M Hite, Shravani Enduri, Yu-Shiuan Cheng, Beatriz Feijo, Graham Kang, Nana Arhin, Hong Zeng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Results in chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mikhail LinetskyDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
Anshula MondalDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
Si-Yang LiuDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
Abby M HiteDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
Shravani EnduriDepartment of Biology, Case Western Reserve University, Cleveland, OH 44106.
Yu-Shiuan ChengDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
Beatriz FeijoDepartment of Biology, Case Western Reserve University, Cleveland, OH 44106.
Graham KangDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
Nana ArhinDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH 44106.
Hong ZengDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
Olivia R LaniakDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
John DenkerDepartment of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106.
Robert G SalomonDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
REACTIVE INTERMEDIATES OF OXIDATIVE LIPID FRAGMENTATIONR01EY016813 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SALOMON, ROBERT GERD · 2006 to 2018
$3.9M
Glutathionylated Products of Radical-Induced Lipid Oxidation in Inflammatory DiseaseR01EY034075 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Robert Gerd Salomon · 2023 to 2026
$1.7M
NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY016813NEI NIH HHS R01 EY034075
6 · The paper itself

Abstract

γ-Hydroxyalkenals, 4-hydroxynonenal (HNE) and phospholipid esters of 4-hydroxy-8-oxooctenoic acid (HOOA-PL), are produced from the alkyl and carboxyl termini of arachidonyl phospholipids by radical-induced oxidative cleavage. Metabolism of HNE by Michael addition of glutathione (GSH) followed by reduction of the aldehyde carbonyl produces a GSH derivative of 1,4-dihydroxynonane (DHN)-GSH. Analogous biochemistry was anticipated to produce a GSH derivative of 5,8-dihydroxyoctanoic acid (DHOA-GSH) that has structural and functional similarity to the cysteinyl leukotriene (LT)C

Indexed as

Free radical-induced lipid oxidationHypoxia-inducible factorPseudo leukotrienesRetinal Pigment Epithelial Cells

Identifiers

PMID38855016
PMCPMC11160973

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.