Evidence map›Paper›PMID 38854954›Full record

ArticleEuropean heart journal open2024

Gene expression and ultra-structural evidence for metabolic derangement in the primary mitral regurgitation heart.

Mariame Selma Kane, Juan Xavier Masjoan Juncos, Shajer Manzoor, Maximiliano Grenett, Joo-Yeun Oh, Betty Pat, Mustafa I Ahmed, Clifton Lewis, James E Davies, Thomas S Denney and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mariame Selma KaneDivision of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham (UAB), 1900 University Boulevard, Birmingham, AL 35233, USA.ORCID https://orcid.org/0000-0003-2981-8482
Juan Xavier Masjoan JuncosDivision of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham (UAB), 1900 University Boulevard, Birmingham, AL 35233, USA.ORCID https://orcid.org/0009-0003-8122-4320
Shajer ManzoorDivision of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham (UAB), 1900 University Boulevard, Birmingham, AL 35233, USA.ORCID https://orcid.org/0000-0002-5899-0006
Maximiliano GrenettDivision of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham (UAB), 1900 University Boulevard, Birmingham, AL 35233, USA.ORCID https://orcid.org/0009-0006-3524-0081
Joo-Yeun OhDivision of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham (UAB), 1900 University Boulevard, Birmingham, AL 35233, USA.ORCID https://orcid.org/0000-0003-3912-9074
Betty PatDivision of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham (UAB), 1900 University Boulevard, Birmingham, AL 35233, USA.ORCID https://orcid.org/0000-0003-1280-1457
Mustafa I AhmedDivision of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham (UAB), 1900 University Boulevard, Birmingham, AL 35233, USA.ORCID https://orcid.org/0000-0003-0885-8645
Clifton LewisDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Alabama at Birmingham (UAB), 1808 7th Avenue, Birmingham, AL 35294, USA.ORCID https://orcid.org/0000-0002-8304-8485
James E DaviesDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Alabama at Birmingham (UAB), 1808 7th Avenue, Birmingham, AL 35294, USA.ORCID https://orcid.org/0000-0003-2400-4025
Thomas S DenneySamuel Ginn College of Engineering, Auburn University, 345 W Magnolia Ave, Auburn, AL 36849, USA.ORCID https://orcid.org/0000-0002-6695-4777
Jonathan McConathyDepartment of Radiology, University of Albama (UAB), 619 19th Street South, Birmingham, AL 35294, USA.ORCID https://orcid.org/0000-0003-4681-2322
Louis J Dell'ItaliaDivision of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham (UAB), 1900 University Boulevard, Birmingham, AL 35233, USA.ORCID https://orcid.org/0000-0001-6654-0665

Funding

Vaso-Hormonal Mechanisms in HypertensionP01HL051952 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GROBAN, LEANNE · 1994 to 2019
$34.8M
The Impact on Diabetes on Left Ventricular RemodelingP50HL077100 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DELL'LTALIA, LOUIS · 2005 to 2009
$16.5M
The Chymase Angiotensin-(1-12) Axis in Heart DiseaseI01CX000993 · VA · BIRMINGHAM VA MEDICAL CENTER · PI DELL'ITALIA, LOUIS J. · 2014 to 2017
–
CSRD VA I01 CX000993NHLBI NIH HHS P01 HL051952NHLBI NIH HHS P50 HL077100
6 · The paper itself

Abstract

Aims: Chronic neurohormonal activation and haemodynamic load cause derangement in the utilization of the myocardial substrate. In this study, we test the hypothesis that the primary mitral regurgitation (PMR) heart shows an altered metabolic gene profile and cardiac ultra-structure consistent with decreased fatty acid and glucose metabolism despite a left ventricular ejection fraction (LVEF) > 60%. Methods and results: Metabolic gene expression in right atrial (RA), left atrial (LA), and left ventricular (LV) biopsies from donor hearts ( Conclusion: The PMR heart has a global ultra-structural and metabolic gene expression pattern of decreased glucose uptake along with increased glycogen and LDs. Further studies must determine whether this presentation is an adaptation or maladaptation in the PMR heart in the clinical evaluation of PMR.

Indexed as

[18F]FDG-PET/CMRLipid and glucose metabolismMitochondria dysfunctionPrimary mitral regurgitation

Identifiers

PMID38854954
PMCPMC11157345

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.