Evidence map›Paper›PMID 38854545›Full record

ArticleACS omega2024

Antibacterial Antimicrobial Peptide Grafted HA/SF/Alg Wound Dressing Containing AIEgens for Infected Wound Treating.

Yize Lin, Yan Tan, Rong Deng, Li Gong, Xiaoshan Feng, Zhongqi Cai, Yanxian He, Longbao Feng, Biao Cheng, Yi Chen

Abstract read
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Application of Antimicrobial Peptides in Wound Dressings.Drug design, development and therapy · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yize LinGraduate School, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006, P. R. China.
Yan TanDepartment of Cadre Ward, General Hospital of Southern Theater Command, PLA, Guangzhou 510010, P. R. China.
Rong DengDepartment of Health Medicine, General Hospital of Southern Theater Command, PLA, Guangzhou 510010, P. R. China.
Li GongDepartment of Cadre Ward, General Hospital of Southern Theater Command, PLA, Guangzhou 510010, P. R. China.
Xiaoshan FengDepartment of Cadre Ward, General Hospital of Southern Theater Command, PLA, Guangzhou 510010, P. R. China.
Zhongqi CaiDepartment of Cadre Ward, General Hospital of Southern Theater Command, PLA, Guangzhou 510010, P. R. China.
Yanxian HeDepartment of Cadre Ward, General Hospital of Southern Theater Command, PLA, Guangzhou 510010, P. R. China.
Longbao FengKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, P. R. China.
Biao ChengDepartment of Burns and Plastic Surgery, General Hospital of Southern Theater Command, PLA, Guangzhou 510010, P. R. China.
Yi ChenDepartment of Cadre Ward, General Hospital of Southern Theater Command, PLA, Guangzhou 510010, P. R. China.ORCID https://orcid.org/0009-0009-2594-7608

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds are characterized with excessive biofluid and persistent infection. Therefore, there is an urgent desire to develop a multifunctional wound dressing that can meet the extreme requirements including effective antibacterial and powerful wound microenvironment regulation and protection function to promote wounds heal quickly. In this study, a multifunctional composite dressing (HA-AMP/SF/Alg/Rb-BG-AIEgens) was synthesized by combining a mesoporous bioactive glass framework loaded with AIEgens (Rb-BG-AIEgens) with cross-linked antimicrobial peptide grafted hyaluronic acid (HA-AMP), sodium alginate (Alg), and silk fibroin (SF). It is important to note that the Rb-BG-AIEgens can achieve real-time and sensitive bacterial detection. HA-AMP can achieve broad spectrum antibacterial and avoid the residue of drug-resistant bacteria. The HA-AMP/SF/Alg/Rb-BG-AIEgens dressing can up-regulate related proliferative proteins, thereby promoting regeneration of tissue and the rapid healing of chronic wounds. With good biocompatibility and antibacterial ability, HA-AMP/SF/Alg/Rb-BG-AIEgens dressing has great potential to become a next generation wound dressing for clinical biological fluid management and chronic bacterial infection treatment.

Identifiers

PMID38854545
PMCPMC11154921

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.