Evidence map›Paper›PMID 38854427›Full record

ArticleFrontiers in genetics2024

A novel locus in

Delesa Damena, Amadou Barry, Robert Morrison, Santara Gaoussou, Almahamoudou Mahamar, Oumar Attaher, Djibrilla Issiaka, Yahia Dicko, Alassane Dicko, Patrick Duffy and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Delesa DamenaMolecular Pathogenesis and Biomarkers Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Amadou BarryMalaria Research and Training Center, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Robert MorrisonPathogenesis and Immunity Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Santara GaoussouMalaria Research and Training Center, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Almahamoudou MahamarMalaria Research and Training Center, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Oumar AttaherMalaria Research and Training Center, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Djibrilla IssiakaMalaria Research and Training Center, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Yahia DickoMalaria Research and Training Center, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Alassane DickoMalaria Research and Training Center, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Patrick DuffyPathogenesis and Immunity Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Michal FriedMolecular Pathogenesis and Biomarkers Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Funding

Malaria Pathogenesis in Pregnant Women and Young ChildrenZIAAI001153 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FRIED, MICHAL · 2011 to 2025
$9.5M
6 · The paper itself

Abstract

Background: Methods: Based on our previous genome-wide association studies (GWAS) analysis, candidate genes were selected for in-depth analysis using several criteria including gene-level GWAS scores, functional overlap with malaria pathogenesis, and evidence of association with protection or susceptibility to other infectious or inflammatory diseases. Single Nucleotide Polymorphisms (SNPs) residing within these genes were selected mainly based on Results: Of 182 candidate genes reported in our previous study, 11 genes and 22 SNPs residing in these genes were selected. The selected SNPs were genotyped using KASP technology in 477 DNA samples (87 SM and 390 controls). Logistic regression analysis revealed that a common intron variant, rs13340578 in CUB and Sushi Multi Domain (CSMD1) gene, is associated with increased odds of SM in recessive mode of inheritance (MAF = 0.42, OR = 1.8, 95% CI = [1.78, 1.84], Conclusion: Taken together, the current study showed that an intron variant rs13340578, residing in

Indexed as

candidate genecomplement controlCSMD1severe malariasnps

Identifiers

PMID38854427
PMCPMC11157005

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.