Evidence map›Paper›PMID 38854146›Full record

ArticlebioRxiv : the preprint server for biology2024

Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm.

L S Ee, D Medina-Cano, C M Uyehara, C Schwarz, E Goetzler, E Salataj, A Polyzos, S Madhuranath, T Evans, A K Hadjantonakis and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

L S EeSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
D Medina-CanoDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
C M UyeharaSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
C SchwarzEmerald Cloud Lab, Austin, TX 78728 USA.
E GoetzlerSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
E SalatajSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
A PolyzosSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
S MadhuranathSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
T EvansDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, New York, NY 10065, USA.
A K HadjantonakisDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
E ApostolouSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
T VierbuchenDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
M StadtfeldSanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-5852-9906

Funding

Structure, Function, and Dynamics of Macro-molecular Complexes that Execute and Regulate Genome FunctionRM1GM139738 · NIGMS · CORNELL UNIVERSITY · PI Thomas George Wade Graham, Steven Zvi Josefowicz · 2021 to 2026
$14.4M
Multidisciplinary Research Training in Cardiovascular DiseaseT32HL160520 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Geoffrey S Pitt, Jonathan W. Weinsaft · 2022 to 2026
$2.0M
Organizational principles and functional role of 3D enhancer hubs in cell fate decisionsR01GM138635 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI APOSTOLOU, EFFIE · 2020 to 2023
$1.9M
Dissecting genetic determinants of epigenetic instability in pluripotent stem cellsR01GM145864 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI STADTFELD, MATTHIAS · 2022 to 2025
$1.7M
A transgenic toolbox to dissect molecular pathologies caused by OTX2 deficiency during ex vivo human ectoderm developmentR03NS135564 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI STADTFELD, MATTHIAS · 2024 to 2024
$170k
NHLBI NIH HHS T32 HL160520NIGMS NIH HHS R01 GM138635NIGMS NIH HHS R01 GM145864NIGMS NIH HHS RM1 GM139738NINDS NIH HHS R03 NS135564
6 · The paper itself

Abstract

The molecular mechanisms that drive essential developmental patterning events in the mammalian embryo remain poorly understood. To generate a conceptual framework for gene regulatory processes during germ layer specification, we analyzed transcription factor (TF) expression kinetics around gastrulation and during

Identifiers

PMID38854146
PMCPMC11160813

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.