Evidence map›Paper›PMID 38854100›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Salience Network Segregation Mediates the Effect of Tau Pathology on Mild Behavioral Impairment.

Alexandru D Iordan, Robert Ploutz-Snyder, Bidisha Ghosh, Annalise Rahman-Filipiak, Robert Koeppe, Scott Peltier, Bruno Giordani, Roger L Albin, Benjamin M Hampstead

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Alexandru D IordanResearch Program on Cognition and Neuromodulation Based Interventions (RP-CNBI), Department of Psychiatry, University of Michigan, 4251 Plymouth Rd., Ann Arbor, MI, 48105, USA.ORCID 0000-0002-1391-785X
Robert Ploutz-SnyderApplied Biostatistics Laboratory, School of Nursing, University of Michigan, 426 N Ingalls St, Ann Arbor, MI 48109, USA.
Bidisha GhoshApplied Biostatistics Laboratory, School of Nursing, University of Michigan, 426 N Ingalls St, Ann Arbor, MI 48109, USA.
Annalise Rahman-FilipiakResearch Program on Cognition and Neuromodulation Based Interventions (RP-CNBI), Department of Psychiatry, University of Michigan, 4251 Plymouth Rd., Ann Arbor, MI, 48105, USA.
Robert KoeppeDepartment of Radiology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA.
Scott PeltierFunctional MRI Laboratory, University of Michigan, 2360 Bonisteel Blvd, Ann Arbor, MI 48109, USA.
Bruno GiordaniResearch Program on Cognition and Neuromodulation Based Interventions (RP-CNBI), Department of Psychiatry, University of Michigan, 4251 Plymouth Rd., Ann Arbor, MI, 48105, USA.
Roger L AlbinDepartment of Neurology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0629-608X
Benjamin M HampsteadResearch Program on Cognition and Neuromodulation Based Interventions (RP-CNBI), Department of Psychiatry, University of Michigan, 4251 Plymouth Rd., Ann Arbor, MI, 48105, USA.

Funding

Treating mild cognitive impairment with transcranial direct current stimulationR01AG058724 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMPSTEAD, BENJAMIN MICHAEL · 2018 to 2022
$8.4M
Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI)R35AG072262 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMPSTEAD, BENJAMIN MICHAEL · 2021 to 2025
$4.2M
NIA NIH HHS R01 AG058724NIA NIH HHS R35 AG072262
6 · The paper itself

Abstract

introductionA recently developed mild behavioral impairment (MBI) diagnostic framework standardizes the early characterization of neuropsychiatric symptoms in older adults. However, the links between MBI, brain function, and Alzheimer's disease (AD) biomarkers are unclear.

methodsUsing data from 128 participants with diagnosis of amnestic mild cognitive impairment and mild dementia - Alzheimer's type, we test a novel model assessing direct relationships between AD biomarker status and MBI symptoms, as well as mediated effects through segregation of the salience and default-mode networks.

resultsWe identified a mediated effect of tau positivity on MBI through functional segregation of the salience network from the other high-level, association networks. There were no direct effects of AD biomarkers status on MBI. DISCUSSION: Our findings suggest an indirect role of tau pathology in MBI through brain network dysfunction and emphasize the role of the salience network in mediating relationships between neuropathological changes and behavioral manifestations.

Indexed as

biomarkersbrain connectivityfunctional magnetic resonance imaging (fMRI)network analysisneuropsychiatric symptomspositron emission tomography (PET)resting state

Identifiers

PMID38854100
PMCPMC11160832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.