Evidence map›Paper›PMID 38854069›Full record

ArticlebioRxiv : the preprint server for biology2024

Hybrid Quadrupole Mass Filter - Radial Ejection Linear Ion Trap and Intelligent Data Acquisition Enable Highly Multiplex Targeted Proteomics.

Philip M Remes, Cristina C Jacob, Lilian R Heil, Nicholas Shulman, Brendan X MacLean, Michael J MacCoss

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Philip M RemesThermo Fisher Scientific, 355 River Oaks Parkway, San Jose, California 95134.ORCID 0000-0003-0567-4541
Cristina C JacobThermo Fisher Scientific, 355 River Oaks Parkway, San Jose, California 95134.ORCID 0000-0003-2652-3865
Lilian R HeilThermo Fisher Scientific, 355 River Oaks Parkway, San Jose, California 95134.ORCID 0000-0002-9462-7327
Nicholas ShulmanDepartment of Genome Sciences, University of Washington, 3720 15th St. NE, Seattle WA 98195.ORCID 0000-0003-1674-0794
Brendan X MacLeanDepartment of Genome Sciences, University of Washington, 3720 15th St. NE, Seattle WA 98195.ORCID 0000-0002-9575-0255
Michael J MacCossDepartment of Genome Sciences, University of Washington, 3720 15th St. NE, Seattle WA 98195.ORCID 0000-0003-1853-0256

Funding

Project 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2020 to 2024
$15.9M
Seattle Quant: A Resource for the Skyline Software EcosystemR24GM141156 · NIGMS · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 2021 to 2026
$6.7M
Quantifying proteins in plasma do democratize personalized medicine for patients with type 1 diabetesU01DK137097 · NIDDK · UNIVERSITY OF WASHINGTON · PI ANDREW N HOOFNAGLE, Michael MacCoss · 2023 to 2026
$3.4M
NIA NIH HHS U19 AG065156NIDDK NIH HHS U01 DK137097NIGMS NIH HHS R24 GM141156
6 · The paper itself

Abstract

Targeted mass spectrometry (MS) methods are powerful tools for selective and sensitive analysis of peptides identified by global discovery experiments. Selected reaction monitoring (SRM) is currently the most widely accepted MS method in the clinic, due to its reliability and analytical performance. However, due to limited throughput and the difficulty in setting up and analyzing large scale assays, SRM and parallel reaction monitoring (PRM) are typically used only for very refined assays of on the order of 100 targets or less. Here we introduce a new MS platform with a quadrupole mass filter, collision cell, linear ion trap architecture that has increased acquisition rates compared to the analogous hardware found in the Orbitrap

Identifiers

PMID38854069
PMCPMC11160808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.