Evidence map›Paper›PMID 38854058›Full record

ArticlebioRxiv : the preprint server for biology2025

CryoDRGN-AI: Neural

Axel Levy, Rishwanth Raghu, J Ryan Feathers, Michal Grzadkowski, Frédéric Poitevin, Jake D Johnston, Francesca Vallese, Oliver Biggs Clarke, Gordon Wetzstein, Ellen D Zhong

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Axel LevyDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7890-9562
Rishwanth RaghuDepartment of Computer Science, Princeton University, Princeton, NJ, USA.ORCID 0009-0006-6651-142X
J Ryan FeathersDepartment of Computer Science, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-4402-4659
Michal GrzadkowskiDepartment of Computer Science, Princeton University, Princeton, NJ, USA.
Frédéric PoitevinSLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID 0000-0002-3181-8652
Jake D JohnstonDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Francesca ValleseDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0003-4524-6605
Oliver Biggs ClarkeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0003-1876-196X
Gordon WetzsteinDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9243-6885
Ellen D ZhongDepartment of Computer Science, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-6345-1907

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Architecture, dynamics and regulation of erythrocyte ankyrin-1 complexesR01HL168178 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Oliver Biggs Clarke · 2023 to 2026
$2.4M
NHLBI NIH HHS R01 HL168178NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

Proteins and other biomolecules form dynamic macromolecular machines that are tightly orchestrated to move, bind, and perform chemistry. Cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) can access the intrinsic heterogeneity of these complexes and are therefore key tools for understanding their function. However, 3D reconstruction of the collected imaging data presents a challenging computational problem, especially without any starting information, a setting termed

Identifiers

PMID38854058
PMCPMC11160740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.