Evidence map›Paper›PMID 38854057›Full record

ArticlebioRxiv : the preprint server for biology2024

Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain.

Silas A Buck, Samuel J Mabry, Jill R Glausier, Tabitha Banks-Tibbs, Caroline Ward, Jenesis Gayden Kozel, Chen Fu, Kenneth N Fish, David A Lewis, Ryan W Logan and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Silas A BuckCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9476-9210
Samuel J MabryDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-4856-4481
Jill R GlausierDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-9838-3414
Tabitha Banks-TibbsDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-0193-9816
Caroline WardDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-7296-9732
Jenesis Gayden KozelCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9826-1713
Chen FuDepartment of Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Kenneth N FishDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-1774-3815
David A LewisDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-3225-6778
Ryan W LoganDepartment of Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-8579-015X
Zachary FreybergDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6460-0118

Funding

Predoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0M
CLINICAL RESEARCH TRAINING IN LATE-LIFE MOOD DISORDERST32MH019986 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Carmen Andreescu · 1997 to 2026
$6.9M
Novel roles of VGLUT in sex differences in dopamine neuron vulnerability to environmental toxicant-induced neurodegenerationR01ES034037 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZACHARY FREYBERG · 2023 to 2026
$2.3M
Interinstitutional Program in Cell and Molecular Biology: A Graduate Training Path to Promote Traditional and Non-Traditional Professional OutcomesT32GM133353 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRODSKY, JEFFREY L., MURRAY, SANDRA ANN · 2020 to 2024
$1.5M
Mechanisms for Preserving Neurons in Alzheimer's Disease-Related Dementias Across Drosophila and Mouse ModelsR21AG068607 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY · 2020 to 2021
$430k
Dissecting the functional relevance of unique subpopulations of striatal dopamine receptors in opioid use disorderR36DA057972 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOZEL, JENESIS · 2023 to 2024
$108k
NIA NIH HHS R21 AG068607NIDA NIH HHS R36 DA057972NIEHS NIH HHS R01 ES034037NIGMS NIH HHS T32 GM133353NIMH NIH HHS T32 MH019986NINDS NIH HHS T32 NS007433
6 · The paper itself

Abstract

Age-related dopamine (DA) neuron loss is a primary feature of Parkinson's disease. However, it remains unclear whether similar biological processes occur during healthy aging, albeit to a lesser degree. We therefore determined whether midbrain DA neurons degenerate during aging in mice and humans. In mice, we identified no changes in midbrain neuron numbers throughout aging. Despite this, we found age-related decreases in midbrain mRNA expression of tyrosine hydroxylase (

Indexed as

agingdopamineglutamateneurodegenerationribosometyrosine hydroxylasevesicular glutamate transporter 2

Identifiers

PMID38854057
PMCPMC11160743

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.