Evidence map›Paper›PMID 38854052›Full record

ArticleResearch square2024

Limited Immunogenicity of an HLA-A*03:01-restricted Epitope of Erv-k-env in Non-hiv-1 Settings: Implications for Adoptive Cell Therapy in Cancer.

Erin E Grundy, Lauren C Shaw, Loretta Wang, Daniel J Powell, Mario Ostrowski, R Brad Jones, C Russell Y Cruz, Heather Gordish-Dressman, Catherine M Bollard, Katherine B Chiappinelli

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Erin E GrundyGeorge Washington University.
Lauren C ShawUniversity of Pennsylvania.
Loretta WangGeorge Washington University.
Daniel J PowellUniversity of Pennsylvania.
Mario OstrowskiUniversity of Toronto.
R Brad JonesWeill Cornell Graduate School of Medical Medical Sciences.
C Russell Y CruzChildren's National Hospital.
Heather Gordish-DressmanChildren's National Hospital.
Catherine M BollardChildren's National Hospital.
Katherine B ChiappinelliGeorge Washington University.

Funding

Regulation of repetitive elements in cancer by P53 and epigenetic mechanismsR37CA251270 · NCI · GEORGE WASHINGTON UNIVERSITY · PI Katherine B Chiappinelli · 2021 to 2026
$2.2M
Epigenetic activation of the interferon response to sensitize cancers to immune therapyR00CA204592 · NCI · GEORGE WASHINGTON UNIVERSITY · PI CHIAPPINELLI, KATHERINE B · 2017 to 2019
$747k
Combining repetitive element-specific T cells with epigenetic therapy to treat ovarian cancerF31CA271788 · NCI · GEORGE WASHINGTON UNIVERSITY · PI GRUNDY, ERIN ELIZABETH · 2022 to 2024
$97k
NCI NIH HHS F31 CA271788NCI NIH HHS R00 CA204592NCI NIH HHS R37 CA251270
6 · The paper itself

Abstract

Repetitive elements (REs) are often expressed at higher levels in tumor cells than normal cells, implicating these genomic regions as an untapped pool of tumor-associated antigens. In ovarian cancer (OC), protein from the RE ERV-K is frequently expressed by tumor cells. Here we determined whether the targeting of a previously identified immunogenic epitope in the envelope gene

Indexed as

Endogenous retrovirusesImmunotherapyRepetitive elementsT cell receptorTumor immunology

Identifiers

PMID38854052
PMCPMC11160923

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.