Evidence map›Paper›PMID 38854040›Full record

ArticlebioRxiv : the preprint server for biology2024

Chromatin profiling identifies putative dual roles for H3K27me3 in regulating transposons and cell type-specific genes in choanoflagellates.

James M Gahan, Lily W Helfrich, Laura A Wetzel, Natarajan V Bhanu, Zuo-Fei Yuan, Benjamin A Garcia, Rob Klose, David S Booth

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

James M GahanDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-7043-4873
Lily W HelfrichHoward Hughes Medical Institute / University of California, Berkeley, Department of Molecular and Cell Biology, Berkeley, CA 94720.
Laura A WetzelHoward Hughes Medical Institute / University of California, Berkeley, Department of Molecular and Cell Biology, Berkeley, CA 94720.
Natarajan V BhanuDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.
Zuo-Fei YuanCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Benjamin A GarciaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.
Rob KloseDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID 0000-0002-8726-7888
David S BoothDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-4724-4702

Funding

The ancestry of animal cell differentiation and pluripotencyR35GM147404 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David Scott Booth · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM147404Wellcome Trust
6 · The paper itself

Abstract

Gene expression is tightly controlled during animal development to allow the formation of specialized cell types. Our understanding of how animals evolved this exquisite regulatory control remains elusive, but evidence suggests that changes in chromatin-based mechanisms may have contributed. To investigate this possibility, here we examine chromatin-based gene regulatory features in the closest relatives of animals, choanoflagellates. Using

Identifiers

PMID38854040
PMCPMC11160669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.