ArticleResearch square2024
Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity.
Jiaqi Ma, Cory M Ayres, Chad A Brambley, Smita S Chandran, Tatiana J Rosales, Steven A Corcelli, Evgenii L Kovrigin, Christopher A Klebanoff, Brian M Baker
Abstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Cory M AyresDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.ORCID 0000-0001-9846-8020 Chad A BrambleyDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Smita S ChandranHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.
Tatiana J RosalesDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Steven A CorcelliDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Evgenii L KovriginDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Christopher A KlebanoffHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.ORCID 0000-0001-9645-3896 Brian M BakerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.ORCID 0000-0002-0864-0964 Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MUser Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2MTR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BUTCHER, SAMUEL E · 2012 to 2019
$9.4MTechnologies for Solid-State NMR Data CollectionP41GM136463 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WESTLER, WILLIAM MILO · 2021 to 2025
$6.4MNMR User Program at NMRFAMR24GM141526 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$6.4MMolecular mechanisms of T cell responses to a clonal neoantigen resulting from a mutated driver oncogene.R37CA259177 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Christopher Austin Klebanoff · 2021 to 2026
$3.1MTOX-driven CD8 T cell differentiation and dysfunction in tumorsR01CA269733 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Andrea Schietinger · 2023 to 2026
$2.4MNovel cell therapy approaches for molecularly defined subsets of therapy-resistant melanomaR01CA286507 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Christopher Austin Klebanoff · 2023 to 2026
$1.8MIntegrated state-of-the-art LC-MS/NMR system for the University of WisconsinS10RR025062 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2008 to 2008
$1.7MUpgrade of the NMRFAM 750 MHz NMR SpectrometerS10RR029220 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2010 to 2010
$766kNMR Spectrometer System Optimized for Direct 13C or 15N DetectionS10RR023438 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2008 to 2008
$500kNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA269733NCI NIH HHS R01 CA286507NCI NIH HHS R37 CA259177NCRR NIH HHS S10 RR023438NCRR NIH HHS S10 RR025062NCRR NIH HHS S10 RR029220NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P41 GM103399NIGMS NIH HHS P41 GM136463NIGMS NIH HHS R24 GM141526
6 · The paper itselfAbstract
The inherent cross-reactivity of the T cell receptor (TCR) is balanced by high specificity, which often manifests in confounding ways not easily interpretable from static structures. We show here that TCR discrimination between an HLA-A*03:01 (HLA-A3)-restricted public neoantigen derived from mutant
Identifiers
PMID38854019
PMCPMC11160895
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