Evidence map›Paper›PMID 38854012›Full record

ArticlebioRxiv : the preprint server for biology2024

Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy.

Taylor R Valentino, Benjamin I Burke, Gyumin Kang, Jensen Goh, Cory M Dungan, Ahmed Ismaeel, C Brooks Mobley, Michael D Flythe, Yuan Wen, John J McCarthy

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Taylor R ValentinoDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY.
Benjamin I BurkeDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY.ORCID 0000-0003-0228-1750
Gyumin KangDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY.
Jensen GohDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY.
Cory M DunganDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY.
Ahmed IsmaeelDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY.
C Brooks MobleyDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY.
Michael D FlytheUSDA Agriculture Research Service, Forage-Animal Production Research Unit, University of Kentucky, Lexington, KY.
Yuan WenDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY.
John J McCarthyDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY.

Funding

The role of the gut microbiota in sarcopeniaR21AG071888 · NIA · UNIVERSITY OF KENTUCKY · PI MCCARTHY, JOHN JOSEPH · 2021 to 2022
$406k
NIA NIH HHS R21 AG071888
6 · The paper itself

Abstract

Regular exercise yields a multitude of systemic benefits, many of which may be mediated through the gut microbiome. Here, we report that cecal microbial transplants (CMTs) from exercise-trained vs. sedentary mice have modest benefits in reducing skeletal muscle atrophy using a mouse model of unilaterally hindlimb-immobilization. Direct administration of top microbial-derived exerkines from an exercise-trained gut microbiome preserved muscle function and prevented skeletal muscle atrophy.

Identifiers

PMID38854012
PMCPMC11160717

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.