Evidence map›Paper›PMID 38853969›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Listener effort quantifies clinically meaningful progression of dysarthria in people living with amyotrophic lateral sclerosis.

Indu Navar Bingham, Raquel Norel, Esteban G Roitberg, Julián Peller, Marcos A Trevisan, Carla Agurto, Diego E Shalom, Felipe Aguirre, Iair Embon, Alan Taitz and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Indu Navar BinghamPeter Cohen Foundation dba Everything ALS, Seattle, Washington and Los Altos, California, USA.
Raquel NorelIBM Research Center, Yorktown Heights, NY, USA.ORCID 0000-0001-7737-4172
Esteban G RoitbergPeter Cohen Foundation dba Everything ALS, Seattle, Washington and Los Altos, California, USA.
Julián PellerPeter Cohen Foundation dba Everything ALS, Seattle, Washington and Los Altos, California, USA.
Marcos A TrevisanUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Física - CONICET - Universidad de Buenos Aires, Instituto de Física Interdisciplinaria y Aplicada (INFINA). Buenos Aires, Argentina.
Carla AgurtoIBM Research Center, Yorktown Heights, NY, USA.
Diego E ShalomUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Física - CONICET - Universidad de Buenos Aires, Instituto de Física Interdisciplinaria y Aplicada (INFINA). Buenos Aires, Argentina.
Felipe AguirrePeter Cohen Foundation dba Everything ALS, Seattle, Washington and Los Altos, California, USA.
Iair EmbonPeter Cohen Foundation dba Everything ALS, Seattle, Washington and Los Altos, California, USA.
Alan TaitzSRI International, Menlo Park, CA, USA. This work was performed working at.
Donna HarrisLewis Katz School of Medicine at Temple University, Department of Neurology, Philadelphia, PA, USA.
Amy WrightPeter Cohen Foundation dba Everything ALS, Seattle, Washington and Los Altos, California, USA.
Katie SeaverMGH Institute of Health Professions, Charlestown Massachusetts, MA, USA.
Stacey SullivanSean M. Healey and AMG Center for ALS, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
Jordan R GreenMGH Institute of Health Professions, Charlestown Massachusetts, MA, USA.
Lyle W OstrowLewis Katz School of Medicine at Temple University, Department of Neurology, Philadelphia, PA, USA.
Ernest FraenkelMassachusetts Institute of Technology, Department of Biological Engineering, Cambridge, MA, USA.
James D BerrySean M. Healey and AMG Center for ALS, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0898-6081

Funding

Prolonging Functional Speech in Persons with Amyotrophic Lateral Sclerosis: A Real-Time Virtual Vocal TractK24DC016312 · NIDCD · MGH INSTITUTE OF HEALTH PROFESSIONS · PI GREEN, JORDAN R · 2017 to 2021
$949k
NIDCD NIH HHS K24 DC016312
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative motor neuron disease that causes progressive muscle weakness. Progressive bulbar dysfunction causes dysarthria and thus social isolation, reducing quality of life. The Everything ALS Speech Study obtained longitudinal clinical information and speech recordings from 292 participants. In a subset of 120 participants, we measured speaking rate (SR) and listener effort (LE), a measure of dysarthria severity rated by speech pathologists from recordings. LE intra- and inter-rater reliability was very high (ICC 0.88 to 0.92). LE correlated with other measures of dysarthria at baseline. LE changed over time in participants with ALS (slope 0.77 pts/month; p<0.001) but not controls (slope 0.005 pts/month; p=0.807). The slope of LE progression was similar in all participants with ALS who had bulbar dysfunction at baseline, regardless of ALS site of onset. LE could be a remotely collected clinically meaningful clinical outcome assessment for ALS clinical trials.

Identifiers

PMID38853969
PMCPMC11160879

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.