Evidence map›Paper›PMID 38853940›Full record

ArticlebioRxiv : the preprint server for biology2024

AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model.

Melanie Willimann, Amita Tiyaboonchai, Kei Adachi, Bin Li, Lea Waldburger, Hiroyuki Nakai, Markus Grompe, Beat Thöny

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Melanie WillimannUniversity Children's Hospital Zurich, Division of Metabolism and Children's Research Center, Zurich, Switzerland.
Amita TiyaboonchaiOregon Health & Science University, Stem Cell Center, Portland, Oregon, USA.
Kei AdachiOregon Health & Science University, Department of Molecular & Medical Genetics, Portland, Oregon, USA.
Bin LiOregon Health & Science University, Stem Cell Center, Portland, Oregon, USA.
Lea WaldburgerUniversity Children's Hospital Zurich, Division of Metabolism and Children's Research Center, Zurich, Switzerland.
Hiroyuki NakaiOregon Health & Science University, Department of Molecular & Medical Genetics, Portland, Oregon, USA.
Markus GrompeOregon Health & Science University, Stem Cell Center, Portland, Oregon, USA.ORCID 0000-0002-6616-4345
Beat ThönyUniversity Children's Hospital Zurich, Division of Metabolism and Children's Research Center, Zurich, Switzerland.

Funding

Gene Therapy for DiabetesU01DK123608 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI GROMPE, MARKUS, KAY, MARK A · 2019 to 2022
$2.9M
NIDDK NIH HHS U01 DK123608
6 · The paper itself

Abstract

In gene therapy, delivery vectors are a key component for successful gene delivery and safety, based on which adeno-associated viruses (AAVs) gained popularity in particular for the liver, but also for other organs. Traditionally, rodents have been used as animal models to develop and optimize treatments, but species and organ specific tropism of AAV desire large animal models more closely related to humans for preclinical in-depth studies. Relevant AAV variants with the potential for clinical translation in liver gene therapy were previously evolved

Indexed as

AAV vectorcapsid screeningFRG mouseGene therapylivermouse Xenograftpig

Identifiers

PMID38853940
PMCPMC11160762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.