Evidence map›Paper›PMID 38853884›Full record

ArticlebioRxiv : the preprint server for biology2025

SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy.

Juan J Ferreira, Lindsey N Kent, Ronald McCarthy, Alice Butler, Xiaofeng Ma, Nikita Peramsetty, Chinwendu Amazu, Alexander Zhang, Grace C Whitter, Ethan Li and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Juan J FerreiraDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.ORCID 0000-0001-8175-9067
Lindsey N KentDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Ronald McCarthyDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Alice ButlerDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Xiaofeng MaDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Nikita PeramsettyDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Chinwendu AmazuDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Alexander ZhangDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Grace C WhitterDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Ethan LiDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Sarah K EnglandDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.
Celia M SantiDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, School of Medicine, 425 S. Euclid Avenue, CB 8064, St. Louis, MO 63110, USA.

Funding

A NOVEL MOLECULAR MECHANISM FOR STIMULATING UTERINE CONTRACTILITY BY OXYTOCINR01HD088097 · NICHD · WASHINGTON UNIVERSITY · PI Sarah K. England, Celia M Santi · 2016 to 2026
$4.1M
NICHD NIH HHS R01 HD088097
6 · The paper itself

Abstract

At the end of pregnancy, the uterus transitions from a quiescent to a highly contractile state. This is partly due to depolarization of the resting membrane potential in uterine (myometrial) smooth muscle cells (MSMCs). In human MSMCs, the membrane potential is regulated by a functional complex between the sodium (Na

Indexed as

MyometriumNALCN ChannelsPregnancySLO2.1 ChannelsUterine Contractions

Identifiers

PMID38853884
PMCPMC11160795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.