Evidence map›Paper›PMID 38853871›Full record

ArticlebioRxiv : the preprint server for biology2024

Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis.

Amanda Mixon Blackwell, Yasaman Jami-Alahmadi, Armiyaw S Nasamu, Shota Kudo, Akinobu Senoo, Celine Slam, Kouhei Tsumoto, James A Wohlschlegel, Jose M M Caaveiro, Daniel E Goldberg and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Amanda Mixon BlackwellDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT.ORCID 0000-0002-7473-5822
Yasaman Jami-AlahmadiDepartment of Biological Chemistry, University of California, Los Angeles, CA.ORCID 0000-0001-8289-2222
Armiyaw S NasamuDepartments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-0719-8473
Shota KudoDepartment of Chemistry & Biotechnology, The University of Tokyo, Tokyo, Japan.
Akinobu SenooDepartment of Protein Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Celine SlamDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT.
Kouhei TsumotoDepartment of Chemistry & Biotechnology, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7643-5164
James A WohlschlegelDepartment of Biological Chemistry, University of California, Los Angeles, CA.
Jose M M CaaveiroDepartment of Chemistry & Biotechnology, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-5568-2369
Daniel E GoldbergDepartments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO.
Paul A SigalaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT.ORCID 0000-0002-3464-3042

Funding

RESEARCH TRAINING IN HEMATOLOGYT32DK007115 · NIDDK · UNIVERSITY OF UTAH · PI LEIBOLD, ELIZABETH ANN, PRCHAL, JOSEF T · 1986 to 2020
$8.4M
Comparative Heme Metabolism in Divergent EukaryotesR35GM133764 · NIGMS · UNIVERSITY OF UTAH · PI SIGALA, PAUL A · 2019 to 2023
$2.1M
Genomics Summer Research for Minorities: A Pathway to Promote Diversity in Science ResearchR25HG009886 · NHGRI · UNIVERSITY OF UTAH · PI YOST, H. JOSEPH · 2018 to 2022
$1.3M
Understanding Ubiquitin-dependent Regulation of Iron Metabolism using Mass SpectrometryR35GM153408 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Akira Wohlschlegel · 2024 to 2026
$1.2M
ROLE OF PFHO-1 IN P. FALCIPARUM INTRAERYTHROCYTIC DEVELOPMENTR21AI110712 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2014 to 2015
$408k
NHGRI NIH HHS R25 HG009886NIAID NIH HHS R21 AI110712NIDDK NIH HHS T32 DK007115NIGMS NIH HHS R35 GM133764NIGMS NIH HHS R35 GM153408
6 · The paper itself

Abstract

Malaria parasites have evolved unusual metabolic adaptations that specialize them for growth within heme-rich human erythrocytes. During blood-stage infection,

Identifiers

PMID38853871
PMCPMC11160694

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.