Evidence map›Paper›PMID 38853828›Full record

ArticleResearch square2024

Human tNeurons reveal aging-linked proteostasis deficits driving Alzheimer's phenotypes.

Ching-Chieh Chou, Ryan Vest, Miguel A Prado, Joshua Wilson-Grady, Joao A Paulo, Yohei Shibuya, Patricia Moran-Losada, Ting-Ting Lee, Jian Luo, Steven P Gygi and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Ching-Chieh ChouDepartment of Biology, Stanford University, Stanford, California, USA.
Ryan VestDepartment of Chemical Engineering, Stanford University, Stanford, California, USA.
Miguel A PradoDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4914-1619
Joshua Wilson-GradyDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4291-413X
Yohei ShibuyaDepartments of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Patricia Moran-LosadaWu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, California, USA.
Ting-Ting LeeDepartment of Biology, Stanford University, Stanford, California, USA.
Jian LuoPalo Alto Veterans Institute for Research, Inc. (PAVIR), Palo Alto, California, USA.ORCID 0000-0002-2064-8467
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-7626-0034
Jeffery W KellyDepartment of Chemistry, The Scripps Research Institute, La Jolla, California, USA.ORCID 0000-0001-8943-3395
Daniel FinleyDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-2076-5863
Marius WernigDepartments of Pathology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-5309-515X
Tony Wyss-CorayWu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-5893-0831
Judith FrydmanDepartment of Biology, Stanford University, Stanford, California, USA.ORCID 0000-0003-2302-6943

Funding

Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Lisa Goldman Rosas · 2020 to 2026
$29.0M
The proteasome in aging and neurodegenerative diseaseP01AG054407 · NIA · NORTHWESTERN UNIVERSITY · PI FINLEY, DANIEL J · 2018 to 2022
$14.0M
Working Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI HENDERSON, VICTOR · 2015 to 2019
$7.9M
NIA NIH HHS P01 AG054407NIA NIH HHS P30 AG066515NIA NIH HHS P50 AG047366
6 · The paper itself

Abstract

Aging is a prominent risk factor for Alzheimer's disease (AD), but the cellular mechanisms underlying neuronal phenotypes remain elusive. Both accumulation of amyloid plaques and neurofibrillary tangles in the brain

Identifiers

PMID38853828
PMCPMC11160905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.