Evidence map›Paper›PMID 38853759›Full record

ArticleNMR in biomedicine2024

Brain metabolism after therapeutic hypothermia for murine hypoxia-ischemia using hyperpolarized [1-

Xiaodan Liu, Tiina Manninen, Alkisti Mikrogeorgiou Capper, Xiangning Jiang, Jacob Ellison, Yaewon Kim, Gokce Gurler, Duan Xu, Donna M Ferriero

Abstract read
In one paragraph

Article in NMR in biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaodan LiuDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0003-1500-9086
Tiina ManninenDepartment of Neurology, University of California San Francisco, San Francisco, California, USA.
Alkisti Mikrogeorgiou CapperDepartment of Neurology, University of California San Francisco, San Francisco, California, USA.
Xiangning JiangDepartment of Neurology, University of California San Francisco, San Francisco, California, USA.
Jacob EllisonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Yaewon KimDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Gokce GurlerFaculty of Medicine, Hacettepe University, Ankara, Turkey.
Duan XuDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Donna M FerrieroDepartment of Neurology, University of California San Francisco, San Francisco, California, USA.

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Precision Therapy for Neonatal Brain InjuryR35NS097299 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIERO, DONNA M. · 2017 to 2024
$6.3M
Upgrade of an Obsolete 3.35T DNP Polarizer to enable new HP C-13 Technology DevelopmentS10OD025077 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VIGNERON, DANIEL B · 2020 to 2020
$1.7M
A critical role for microglial cholesterol 25-hydroxylase in regulating neuroinflammation following neonatal brain hypoxia-ischemiaR21NS133533 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JIANG, XIANGNING · 2024 to 2025
$450k
Academy of Finland 326494Academy of Finland 326495Academy of Finland 345280Academy of Finland (decision Nos. 326494, 326495, and 345280)NIBIB NIH HHS P41 EB013598NIH HHS 5P41EB013598NIH HHS S10 OD025077NIH R35 5R35NS097299NINDS NIH HHS R21 NS133533NINDS NIH HHS R35 NS097299Research Council of Finland (decision No. 355256)
6 · The paper itself

Abstract

Hypoxic-ischemic encephalopathy (HIE) is a common neurological syndrome in newborns with high mortality and morbidity. Therapeutic hypothermia (TH), which is standard of care for HIE, mitigates brain injury by suppressing anaerobic metabolism. However, more than 40% of HIE neonates have a poor outcome, even after TH. This study aims to provide metabolic biomarkers for predicting the outcomes of hypoxia-ischemia (HI) after TH using hyperpolarized [1-

Indexed as

BrainHypothermia, InducedHypoxia-Ischemia, BrainPyruvic AcidAnimalsCarbon-13 Magnetic Resonance SpectroscopyCarbon IsotopesMagnetic Resonance SpectroscopyMaleMiceMice, Inbred C57BLCarbon-13Carbon IsotopesPyruvic Acidanaerobic metabolismhyperpolarized [1‐13C] pyruvate MR spectroscopyhypoxic‐ischemic encephalopathytherapeutic hypothermia

Identifiers

PMID38853759
PMCPMC11839149

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.